Anti-Cancer and Anti-Microbial Activity Studies of Some Complexes of Trimethoprim
DOI:
https://doi.org/10.6000/1929-2279.2013.02.01.3Keywords:
Trimethoprim complexes, anti-bacterial activity, anti-cancer activity.Abstract
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, trimethoprim (TMP), was reacted with Cu, Zn, Fe and Ti. The products were characterized by elemental (CHN) analysis, FTIR, magnetic moment measurements, conductance measurements, electronic spectra, 13C spectra. All complexes were investigated for their anti-bacterial activities against Gram-positive and Gram-negative bacteria and were also screened for their in vitro anti-cancer potential using Hela and PC3 cells. All the complexes showed excellent anti-bacterial activity even more than TMP while TMP-Ti displayed good cytotoxic activity in vitro against Hela cells and TMP-Cu showed moderate cytotoxicity against PC3 cells.
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