Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity

• Chao-Zhan Lin

  Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China

• Ai-Zhi Wu

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Ying Zhong

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Yu-Mei Wang

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Guang-Tian Peng

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Xian-Jun Su

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Bing-Xin Liu

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Yun Deng

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

• Chen-Chen Zhu

  Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China

• Cui-Xian Zhang

  School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

In clinical, Psychotria serpens L. was often substitute for Caulis trachelospermi to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In order to search significant anti-cancer active leading compounds, sevenetin (5), rutin (6), kaempferol-3- flavonoids, quercetin (1), tamarixetin-3-O-rutinoside (2), quercetin 3-O-(2G-β-D-xylopyranosy-lrutinoside) (3), kaempferol (4), tamarixO- rutino- side (7) were isolated from P. serpens L., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS. 2-5 were the first isolated from genus Psychotria. All of compounds were the first isolated from P. serpens.

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