Role of Hormones in Oral Squamous Cell Carcinoma - An Update

• Megha Jain

  Department of Oral Pathology and Microbiology, Peoples Dental Academy, Bhopal -462037, Madhya Pradesh, India

• Vipin Jain

  Department of Pharmacology, Peoples College of Medical Sciences and Research Center, Bhopal – 462037, Madhya Pradesh, India

• Anish Gupta

  Department of Oral Pathology and Microbiology, Peoples Dental Academy, Bhopal -462037, Madhya Pradesh, India

• Swati Saawarn

  Department of Oral Pathology and Microbiology, Peoples Dental Academy, Bhopal -462037, Madhya Pradesh, India

• Samar Khan

  Department of Oral Pathology and Microbiology, College of Dentistry, Jazan University, Jazan, KSA

Background: Hormones have been recognized as regulator of the cell growth, differentiation and maturation. It has become increasingly evident that hormone may play a crucial role in the genesis and progression of several cancers like those of breast, ovary, testis, thyroid, prostrate including oral cancer.

Aim: Present overview aims to discuss and provide data on possible role of various hormones including stress hormone, sex hormone, parathyroid and related hormone protein, melatonin and active metabolite of vitamin D3 in causation and progression of Oral squamous cell carcinoma (OSCC).

Data Acquisition: A systematic search of existing literature was carried out for the keywords like hormones and cancer, hormones and oral cancer or OSCC utilizing the Google, Google Scholar and PubMed databases for extraction, assortment and compilation of data.

Inference: In conclusion, we found that hormones are directly or indirectly involved in the pathogenesis of the OSCC and can be utilized in its management and prevention.

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