Frequency and Clinical Impact of KRAS Mutations in Patients with Colorectal Cancer from the Middle East

• Jamal Zekri

  King Faisal Specialist Hospital Research Centre, Oncology, Jeddah, Saudi Arabia

• Syed Mustafa Karim

  College of Medicine, Al-Faisal University, Saudi Arabia

• Ahmed Al-Shehri

  National Guard Hospital, Oncology, Jeddah, Saudi Arabia

• Mervat Mahrous

  King Fahad Hospital, Oncology, Madinah, Saudi Arabia

• Tarek Darwish

  King Abdulaziz Hospital and Oncology Centre, Jeddah, Saudi Arabia

• Hani El Taani

  King Abdullah Medical City, Oncology, Makkah, Saudi Arabia

  Background: Colorectal cancer (CRC) is a significant healthcare burden worldwide and in the Middle East (ME). KRAS mutation confers resistance to epidermal growth factor receptor (EGFR) inhibitors in the treatment of advanced CRC. Data regarding the rate of KRAS mutation from the ME are scattered and scarce. We aim to collect and review all sizable studies evaluating the frequency of KRAS mutations in CRC patients from the ME.

Method: A Pubmed and Google Scholar search was conducted using keywords including KRAS, K-ras, colorectal cancer and Middle East, along with names of each ME country. Studies including over 90 patients were included in the review.

Result: Eleven studies containing more than 90 patients were identified. Among all eleven studies, KRAS mutation rate ranged from 13 to 56%. Five studies reported KRAS mutation rate in M1 stage either exclusively or as part of subgroup analysis. In these studies, mutations were found in 8-45% of cases. KRAS mutations were associated with female gender, M1 stage and high CEA in 3, 2, and 1 studies respectively.

Conclusion: There is a broad range of variability in KRAS mutation rate reported in different studies from the ME. This may have been due to small number of patients in the studies and lack of centralized testing for KRAS mutations. Larger and more coordinated studies from the ME population are required to ascertain the accuracy of KRAS mutation rate.

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