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Apoptozole Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer

Authors

  • Kang-Yao Zeng

    Department of Thoracic Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China

  • Qing-Yi Zhou

    Department of Thoracic Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China

  • Yun-Xi Zhang

    Department of Thoracic Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China

  • Zhe-Sheng Chen

    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York 11432, USA

  • Zhi Shi

    Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China

  • Song-Wang Cai

    Department of Thoracic Surgery, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China

DOI:

https://doi.org/10.30683/1929-2279.2025.14.07

Keywords:

Lung cancer, Multidrug Resistance, ABCG2, Apoptozole, Chemotherapy Sensitivity, Molecular Docking

Abstract

Lung cancer is a widespread malignant tumor with a highmortality rate, often difficult to treat effectively due to chemoresistance. Given the close association between ABCG2 overexpression and cancer multidrug resistance, overcoming the issue of MDR caused by ABCG2 is still a challenge. In this study, we found that the small molecule apoptozole effectively suppresses the transport activity of ABCG2, thus mitigating multidrug resistance in lung cancer cells, overexpressing ABCG2, and improving the therapeutic effects of chemotherapy drugs mitoxantrone and topotecan. Additionally, apoptozole does not affect the expression level of ABCG2 protein. Molecular docking studies have demonstrated that apoptozole can firmly bind to the binding pocket of ABCG2. Our data present that apoptozole is an ABCG2 inhibitor and modulates ABCG2-mediated multidrug resistance in lung cancer.

References

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Published

2025-05-09

Issue

Vol. 14 (2025)

Section

Articles

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Apoptozole Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer. (2025). Journal of Cancer Research Updates, 14, 63-68. https://doi.org/10.30683/1929-2279.2025.14.07

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