Antitumor Activity of Dehydroxymethylepoxyquinomicin (DHMEQ) in Monotherapy and Combination with Cisplatin in the SKOV-3 Ovarian Cancer Model

• Sh.R. Kzyrgalin

  Department of Oncology and Clinical Morphology, Bashkir State Medical University, Ufa, Russian Federation and Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russian Federation

• R.S. Yamidanov

  Department of Oncology and Clinical Morphology, Bashkir State Medical University, Ufa, Russian Federation

• A.A. Rizvanov

  Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kazan, Russian Federation and Division of Medical and Biological Sciences, Tatarstan Academy of Sciences, Kazan, Russian Federation

• Sh.Kh. Gantsev

  Department of Oncology and Clinical Morphology, Bashkir State Medical University, Ufa, Russian Federation and Division of Medical Sciences and Healthcare, Academy of Sciences of the Republic of Bashkortostan, Ufa, Russian Federation

The objective of this study was to evaluate the antitumor activity of DHMEQ as monotherapy and in combination with cisplatin in a human ovarian cancer xenograft model. Cisplatin was used as a comparator. To create the xenograft model, human ovarian cancer cells (SKOV-3 line) were subcutaneously implanted into immunodeficient mice. The study was conducted on female SCID Beige C.B-17 Cg-Prkdcscid Lystbg/Crl mice. Antitumor activity was determined by comparing tumor growth inhibition (TGI) in the treatment groups to that in the control group. Results showed that daily intraperitoneal administration of DHMEQ at a dose of 14 mg/kg following a single intraperitoneal dose of cisplatin at 4 mg/kg reduced tumor growth in the SKOV-3 cell line xenograft model.

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