Cancer: Evidence Consistent with Epigenetic Carcinogenesis

• Patrick A. Riley

  Totteridge Institute for Advanced Studies, London N20 8AB, UK

  https://orcid.org/0000-0001-7527-6800

This brief review outlines the accumulated evidence which favours a mechanism of cancer generation that is dependent on defective vertical transmission of the pattern of epigenetic control of genetic expression. This model is based on the initiating lesion involving the process that copies the epigenetic features when stem cells undergo mitosis.

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