Evaluation of Single-Field Electron Beams for Postmastectomy Radiotherapy
- Authors
-
-
H. Omer
College of Medicine, University of Dammam, the Kingdom of Saudi Arabia -
O.Nasir
Department of Medical Laboratory, Faculty of Applied Medical Sciences Tai'f University the Kingdom of Saudi Arabia -
A. Suleiman
College of Applied Medical Sciences, Prince Salman Bin Abdul Aziz University, Kharj the Kingdom of Saudi Arabia
-
- Keywords:
- Electron irradiation, chest wall, postmastectomy, radiotherapy, Monte Carlo, EGSnrc, DICOM, CT-scans, XSTING, dose-volume histograms
- Abstract
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Introduction:electron beams have been extensively used in postmastectomy radiotherapy due to its homogenous dose at the surface followed by sharp fall-off sparing the underlying tissue. Multiple electron fields or electron photon mix were the techniques commonly used. An old study reported the successful use of single-field electron beams with beam energy of 20 MeV. Yet the potential risks of the organs at risk were not clearly shown.
Objectives:the objectives of this study were to assess the possibility of applying single-field electron beams in postmastectomy radiotherapy in terms of: the dose distribution in the target, the volume of organs that receive a certain threshold dose and the volume of organs that receive low doses of radiation.
Materials and Methods: the Monte Carlo codes of EGSnrc were used to simulate electron beams of different energies and gantry angles. The resulting dose files were used by XSTING to generate dose volume histograms, which were used for evaluation.
Results and Discussions: the target coverage was quite poor in most of the studied scenarios. Improving the target coverage was at the expense of irradiating the lung and heart with unacceptable dose values.
Conclusion and Recommendations: Single field electron beams cannot be used for postmastectomy radiotherapy. Multiple electron fields or photon electron mix are necessary and need to be assessed.
- References
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http://Www.Breastcancersource.Com/Breastcancersourcehcp
Pierce LJ, Butler JB, Martel MK, et al. Postmastectomy Radiotherapy Of The Chest Wall: Dosimetric Comparison Of Common Techniques. Int J Radiation Oncology Biol Phys 2002; 52(5): 1220-30. http://dx.doi.org/10.1016/S0360-3016(01)02760-2
Tsougos I, Nilsson P, Theodorou K, et al. NTCP modeling and pulmonary function tests evaluation for the prediction of radiation induced pneuomonitis in non-small-cell lung cancer radiotherapy. Phys Med Biol 2007; 52: 1055-73. http://dx.doi.org/10.1088/0031-9155/52/4/013
Kawrakow I, Rogers DWO. The EGSnrc Code System: Monte Carlo simulation of electron and photon transport, NRC Report PIRS–701.
Zackirson B, Karlsson M. Matching of electron beams for conformal therapy of target volumes at moderate depths. Radiother Oncol 1996; 39: 261-70. http://dx.doi.org/10.1016/0167-8140(96)01729-X
Højris I, Andersen J, Overgraad M, Overgraad J. Late Treatment Morbidity In Breast Cancer Patients Randomized to Postmastectomy Radiotherapy And Systemic Treatment Versus Systemic Treatment Alone. Acta Oncol 2000; 39: 354-72.
Krueger EA, Schipper MJ, Koelling T, et al. Cardiac Chamber And Coronary Artery Doses Associated With Postmastectomy Radiotherapy Techniques To The Chest Wall And Regional Nodes. Int J Radiation Oncol Biol Phys 2004; 60(4): 1195-203. http://dx.doi.org/10.1016/j.ijrobp.2004.04.026
Lind P, Wemmberg B, Gagliardi G, Fornander T. Pulmonary Complications Following Different Radiotherapy Techniques For Breast Cancer; And The Association To Irradiated Lung Volume And Dose Breast Cancer Research and Treatment 2001; 69: 199-10. http://dx.doi.org/10.1023/A:1012292019599
Theuws JCM, Kwa SLS, Wagenaar AC, et al. Dose-Effect Relations For Early Local Pulmonary Injury After Irradiation for Malignant Lymphoma and Breast Cancer. Radiother Oncol 1998; 48: 33-43. http://dx.doi.org/10.1016/S0167-8140(98)00019-X
Early Breast Cancer Trialists’ Collaborative Group (Ebctcg) Effects of Radiotherapy and of Differences in The Extent of Surgery for Early Breast Cancer On Local Recurrence and 15-Year Survival: An Overview of The Randomised Trials. Lancet 2005; 366: 2087-106.
Clenton SJ, Fisher PM, Conway J, Kirkbride P, Hatton MK. The Use of Lung Dose–Volume Histograms in Predicting Post-radiation Pneumonitis After Non-conventionally Fractionated Radiotherapy for Thoracic Carcinoma. Clin Oncol 2005; 17(8): 599-603. http://dx.doi.org/10.1016/j.clon.2005.07.016
Graham MV, Purdy JA, Emami B, et al. Clinical dose–volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiation Oncol Biol Phys 1999; 45(2): 323-29. http://dx.doi.org/10.1016/S0360-3016(99)00183-2
Gagliardi G, Lax I, Soderstrom S, Gyenes G, Rutqvist LE. Prediction of excess risk of long-term cardiac mortality after radiotherapy of stage I breast cancer. Radiother Oncol 1998; 46(1): 63-71. http://dx.doi.org/10.1016/S0167-8140(97)00167-9
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- Published
- 2012-07-15
- Issue
- Vol. 1 No. 2 (2012)
- Section
- Articles
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