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Efficacy of Chemiluminescence (ViziLite™) as a Screening Method in the Detection of Clinically Suspicious Oral Cancerous and Precancerous Lesions

Authors

  • Antonio Carrera Torres

    Clinical Associate in Oral Medicine, Dental School, University of Seville, Spain

  • Ángel Martínez-Sahuquillo Márquez

    Senior Clinical Lecturer in Oral Medicine, Dental School, University of Seville, Spain

  • Javier Fernández Farhall

    Clinical Lecturer of the Postgraduate Specialty in Periodontics, Department of Health Sciences II, University Rey Juan Carlos, Madrid, Spain

  • María José Cobos Fuentes

    Honorary Lecturer in Oral Medicine, Dental School, University of Seville, Spain

  • Isabel Gallardo Castillo

    Honorary Lecturer in Oral Medicine, Dental School, University of Seville, Spain

DOI:

https://doi.org/10.6000/1927-7229.2013.02.03.8

Keywords:

Chemiluminescence, screening method, oral cancer

Abstract

 Several screening techniques based on light interaction with tissue have been described to aid clinicians in the detection of early oral cancerous lesions. One of the most studied techniques is chemiluminescence. This method has been used in different studies but always by Oral Medicine specialists.

Objective: To evaluate the chemiluminescence system as a screening method in the detection of clinically suspicious cancerous and precancerous oral lesions when used by clinicians without an Oral Medicine Speciality.

Study Design: A total of 100 patients attending the Oral Medicine Unit at the Dental School of the University of Seville were enrolled. All patients were current smokers and were above the age of 40. The clinical examination was performed by dental students who were instructed in the location and recognition of potentially malignant oral disorders, using visual examination and the chemiluminescence test ViziLite Plus  (Zila Pharmaceuticals, Phoenix, AZ, USA). To assess the validity of the chemiluminescence test as a screening method, a visual exam was performed by a specialist in Oral Medicine which was used as a gold-standard.

Results: Conventional oral visual examination by the Oral Medicine Specialist found 13 lesions suspicious for malignancy, out of which 7 were also detected using the chemiluminescence test. Furthermore, 87 patients were diagnosed as lesion-free, of which 49 obtained negative results during the chemiluminescence test and 38 patients had some sort of lesion. With these results, the test yielded a sensitivity of 0.56 and a specificity of 0.56. These results indicate values similar to other studies, in fact lower sensitivity values, possibly due to the lack of experience of the clinician.

Conclusions: The chemiluminescence test (ViziLite Plus) did not present any advantages in terms of cost-benefit compared to conventional examination as a screening method for cancerous and precancerous oral lesions.

References

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Published

2013-08-28

Issue

Vol. 2 No. 3 (2013)

Section

Articles

How to Cite

Efficacy of Chemiluminescence (ViziLite™) as a Screening Method in the Detection of Clinically Suspicious Oral Cancerous and Precancerous Lesions. (2013). Journal of Analytical Oncology, 2(3),  176-181. https://doi.org/10.6000/1927-7229.2013.02.03.8

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