Percutaneous Lung Ablation Combined with Video-Assisted Thoracic Surgery Guided by Three-Dimensional Reconstruction in the Treatment of Multiple Pulmonary Nodules

• Borong Chen

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Renfeng Wang

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Chaoxiang Du

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Zhiliang Huang

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Zhenyang Lin

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Tao Zhang

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Zhonghua Wu

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China

• Guangyu Yao

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

• Yongxing Zhang

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

• Jie Gu

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

• Hong Fan

  Department of Thoracic Surgery, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China and Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

Background: With the wide application of lung cancer screening, the detection rate of multiple pulmonary nodules (MPNs) has increased annually. However, the optimal therapeutic strategy for MPNs has not achieved a consensus. This study aims to report a novel hybrid technique for the treatment of MPNs.

Methods: A total of 8 patients received CT-guided lung microwave ablation combined with video-assisted thoracic surgery from March 2020 to March 2023. Three-dimensional reconstruction was conducted to distinguish the precise localization, predict the resection extent, and conduct the optimal operation procedure for each lung nodule. The clinicopathological characteristics as well as surgical complications and short-term outcomes were recorded.

Results: 8 patients with a total of 18 nodules were treated by our hybrid technique. Two patients had a FEV1％ Pred lower than 90％. The nodules treated by surgery were confirmed as malignant by pathological results with a median size of 9mm.The median size of the nodules treated by ablation was 6mm. The median ablation power used for the nodules was 45 W (range, 40–50W). The ablation time was 5min. The median distance between nodules to pleura was 31mm (range 19-56mm). This hybrid technique did not increase the rate of complication and prolonged hospital stay. During the short term of follow-up, no recurrence occurred in the patients.

Conclusions: We present our experience of percutaneous lung ablation combined with video-assisted thoracic surgery guided by three-dimensional reconstruction in the treatment of multiple pulmonary nodules. This technique provides a minimally invasive and personalized therapy for patients with MPNs.

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