Virchow-Troisier's Node: A Review
DOI:
https://doi.org/10.30683/1927-7229.2023.12.04Keywords:
Virchow-Troisier's node, Troisier’s sign, Virchow’s node, Metastasis, Eponymous sign, Horner’s syndromeAbstract
Virchow-Troisier's node is an eponymous term referring to the enlargement of the left supraclavicular lymph node. It is a significant physical finding that generally indicates the late manifestation of a variety of malignancies. This review article briefly revisits the historical background, epidemiology, anatomical routes of metastasis, clinical presentation, differential diagnosis, and clinical significance of Virchow-Troisier's node.
References
Morgenstern L. The Virchow-Troisier node: a historical note. Am J Surg 1979; 138(5): 703. https://doi.org/10.1016/0002-9610(79)90353-2
Karamanou M, Laios K, Tsoucalas G, Machairas N, Androutsos G. Charles-Emile Troisier (1844-1919) and the clinical description of signal node. J BUON 2014; 19(4): 1133-5.
Adler C, Lubner MG, Menias CO, Lubner SJ, Dahiya N. What's in a node? The clinical and radiologic significance of Virchow's node. Abdom Radiol (NY) 2022; 47(6): 2244-2253. https://doi.org/10.1007/s00261-022-03487-4
Schultz M. Rudolf Virchow. Emerg Infect Dis 2008; 14(9): 1480-1. https://doi.org/10.3201/eid1409.086672
Eisenberg L. Rudolf Ludwig Karl Virchow, where are you now that we need you? Am J Med 1984; 77(3): 524-32. https://doi.org/10.1016/0002-9343(84)90114-1
Drotman DP. Emerging infectious diseases: a brief biographical heritage. Emerg Infect Dis 1998; 4(3): 372-3. https://doi.org/10.3201/eid0403.980307
Brown TM, Fee E. Rudolf Carl Virchow: medical scientist, social reformer, role model. Am J Public Health 2006; 96(12): 2104-5. https://doi.org/10.2105/AJPH.2005.078436
Mizutani M, Nawata S, Hirai I, Murakami G, Kimura W. Anatomy and histology of Virchow's node. Anat Sci Int 2005; 80(4): 193-8. https://doi.org/10.1111/j.1447-073X.2005.00114.x
Zdilla MJ, Aldawood AM, Plata A, Vos JA, Lambert HW. Troisier sign and Virchow node: the anatomy and pathology of pulmonary adenocarcinoma metastasis to a supraclavicular lymph node. Autops Case Rep 2019; 9(1): e2018053. https://doi.org/10.4322/acr.2018.053
Cervin JR, Silverman JF, Loggie BW, Geisinger KR. Virchow's node revisited. Analysis with clinicopathologic correlation of 152 fine-needle aspiration biopsies of supraclavicular lymph nodes. Arch Pathol Lab Med 1995; 119(8): 727-30.
Gupta N, Rajwanshi A, Srinivasan R, Nijhawan R. Pathology of supraclavicular lymphadenopathy in Chandigarh, north India: an audit of 200 cases diagnosed by needle aspiration. Cytopathology 2006; 17(2): 94-6. https://doi.org/10.1111/j.1365-2303.2006.00285.x
Nasuti JF, Mehrotra R, Gupta PK. Diagnostic value of fine-needle aspiration in supraclavicular lymphadenopathy: a study of 106 patients and review of literature. Diagn Cytopathol 2001; 25(6): 351-5. https://doi.org/10.1002/dc.10002
Sandal R, Dhiman P, Sharma P, Gupta M. Virchow's node (Troisier's sign) and testicular carcinoma. QJM 2022; 115(11): 754-755. https://doi.org/10.1093/qjmed/hcac175
Kew MC. Virchow-Troisier's lymph node in hepatocellular carcinoma. J Clin Gastroenterol 1991; 13(2): 217-9. https://doi.org/10.1097/00004836-199104000-00021
López F, Rodrigo JP, Silver CE, Haigentz M Jr, Bishop JA, Strojan P, Hartl DM, Bradley PJ, Mendenhall WM, Suárez C, Takes RP, Hamoir M, Robbins KT, Shaha AR, Werner JA, Rinaldo A, Ferlito A. Cervical lymph node metastases from remote primary tumor sites. Head Neck 2016; 38(Suppl 1): E2374-85. https://doi.org/10.1002/hed.24344
Viacava EP, Pack GT. Significance of supraclavicular signal node in patients with abdominal and thoracic cancer—a study of one hunded and twenty-two cases. Arch Surg 1944; 48: 109-199. https://doi.org/10.1001/archsurg.1944.01230010114002
Galloy AC, Christophe JL, Cambier E, Petein M, Verhelst D. Virchow-Troisier's node in a haemodialysed patient: it is not always cancer. Nephrol Dial Transplant 2005; 20(3): 647-9. https://doi.org/10.1093/ndt/gfh543
Duman U, Yeşıl C, Gündüz M, Denız IK. Isolated left supraclavicular hydatid cyst mimicking Virchow's node. Turk J Gastroenterol 2012; 23(5): 612-4. https://doi.org/10.4318/tjg.2012.0447
Siosaki MD, Souza AT. Images in clinical medicine. Virchow's node. N Engl J Med 2013; 368(6): e7. https://doi.org/10.1056/NEJMicm1204740
Mondal RK, Dutta A, Basu K, Chakraborti S. Virchows node: rare presentation of childhood hepatocellular carcinoma. Indian J Pediatr 2005; 72(2): 177-8. https://doi.org/10.1007/BF02760707
Schwarz KO, Schwartz IS, Marchevsky A. Virchow-Troisier's lymph node as the presenting sign of hepatocellular carcinoma. Mt Sinai J Med 1982; 49(1): 59-62.
Rahman M, Nakayama K, Rahman MT, Katagiri H, Ishibashi T, Miyazaki K. Enlarged Virchow's node as an initial complaint of serous ovarian adenocarcinoma. Eur J Gynaecol Oncol 2012; 33(5): 546-8.
Maslovsky I, Gefel D. Virchow's node and Horner's syndrome. Am J Med 2006; 119(2): 180-1. https://doi.org/10.1016/j.amjmed.2005.07.067
Werner RA, Andree C, Javadi MS, Lapa C, Buck AK, Higuchi T, Pomper MG, Gorin MA, Rowe SP, Pienta KJ. A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging. Urology 2018; 117: 18-21. https://doi.org/10.1016/j.urology.2018.03.030
Cham D, Henderson R, Conti PS. Virchow's Node on F-18 FDG PET/CT. Clinical Nuclear Medicine 2004; 29(11): 770-772. https://doi.org/10.1097/00003072-200411000-00035
de la Riva-Pérez PA, García-Gómez FJ, Buján-Lloret C, Calvo-Morón MC, Castro-Montaño J. Virchow Node from Prostate Carcinoma by 18F-Choline PET/CT. Clin Nucl Med 2018; 43(4): 271-272. https://doi.org/10.1097/RLU.0000000000001975
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Similar Articles
- Sajad Ahmad Salati, Lamees Sulaiman Alsulaim, Sister Mary Joseph Nodule (SMJN) – A Review , Journal of Analytical Oncology: Vol. 12 (2023)
- Guan Min Lai, Jen-Tsun Lin , Cheng-Shyong Chang , Metastatic Bone Marrow Tumors Manifested by Hematologic Disorders: Study of Thirty-Four Cases and Review of Literature , Journal of Analytical Oncology: Vol. 3 No. 4 (2014)
- Mehmet Fuat Eren, Ayfer Ay Eren, Birsen Yücel, Seher Bahar, Ahmet Cinkaya, Rayna K. Matsuno, Nuran Beşe, Association between Molecular Subtypes and Survival in Patients with Breast Cancer , Journal of Analytical Oncology: Vol. 6 No. 3 (2017)
- Ravoori Harish Babu, Amritha Prabha Shankar, Geeta S. Narayanan, Ganesh M. Subramanya, B.R. Kiran Kumar, Association of Level III Axillary Lymph Node Positivity with Clinicopathological Characteristics in Breast Cancer , Journal of Analytical Oncology: Vol. 13 (2024)
- Vincent Éthier, Marie-Claude Foley, Sarah Higgins, Régen Drouin, Julie Abel, Rabia Temmar, Rami Kotb, Hans Knecht, Overwhelming Paroxysmal Nocturnal Haemoglobinuria in a Patient with Low-Risk Myelodysplastic Syndrome and Long-Term Anticoagulation for Sick Sinus Syndrome , Journal of Analytical Oncology: Vol. 2 No. 1 (2013)
- Sajad Ahmad Salati, Mohammed Alfehaid, Lamees Sulaiman Alsulaim, Saleh Ahmad Alsuwaydani, Mohammed Ahmed Elmuttalut, Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis , Journal of Analytical Oncology: Vol. 12 (2023)
- Anshika N. Singh, Anand P. Khandwekar , Neeti Sharma, Cancer Stem-Cell Related miRNAs: Novel Potential Targets for Metastatic Prostate Cancer , Journal of Analytical Oncology: Vol. 4 No. 4 (2015)
- Xin Liu, Yan Chen, Zhi Ping Wu, Cong Guo Jin, Xiao Qun Chen, Jia Li, Yong Chun Zhou, Xi Cai Wang, A DNA Vaccine Targeting the Fetal Liver Kinase-1 (Flk-1) can Activate the Special CD8+ T Cell and Inhibit the Metastasis of Orthotopic Lewis Lung Cancer Model , Journal of Analytical Oncology: Vol. 2 No. 4 (2013)
- Rufino Echegoyen-Carmona, Daniel Mendoza-Posada, Catalina Camacho-Mendoza, Oswaldo Rafael Sánchez-Campos, Clinical Issues and Treatment of Lung Cancer in Mexico , Journal of Analytical Oncology: Vol. 1 No. 1 (2012)
- Dimitra Thomaidou , Evangelia Patsavoudi , Extracellular HSP90 in Cancer Invasion and Metastasis: From Translational Research to Clinical Prospects , Journal of Analytical Oncology: Vol. 4 No. 4 (2015)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- Sajad Ahmad Salati, Lamees Alsulaim, Ajaz A Rather, Paget’s Disease of the Breast (PDB) – A Review , Journal of Analytical Oncology: Vol. 11 (2022)
- Sajad Ahmad Salati, Amjaad Alkhezzi, Mohammad Ahmed Elmuttalut, Muhammad Munir Memon, Mushhood Memon, Multiple Primary Malignant Tumours , Journal of Analytical Oncology: Vol. 12 (2023)
- Sajad Ahmad Salati, Lamees Sulaiman Alsulaim, Sister Mary Joseph Nodule (SMJN) – A Review , Journal of Analytical Oncology: Vol. 12 (2023)
- Sajad Ahmad Salati, Mohammed Alfehaid, Lamees Sulaiman Alsulaim, Saleh Ahmad Alsuwaydani, Mohammed Ahmed Elmuttalut, Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis , Journal of Analytical Oncology: Vol. 12 (2023)