Effective and Rapid Osteoclast Inhibition by Denosumab, is Reflected in Serum C Telopeptide (CTX), Across Different Tumor Types

• S. Tuyls

  Depts. of Medical Oncology, Regional Hospital Sint Maria, Ziekenhuislaan 100, 1500 Halle, Belgium

• F. Geurs

  Depts. of Medical Oncology, Regional Hospital Sint Maria, Ziekenhuislaan 100, 1500 Halle, Belgium

• Y. Deprest

  Laboratory, Regional Hospital Sint Maria, Ziekenhuislaan 100, 1500 Halle, Belgium

Denosumab, a monoclonal antibody against RANKL has superior efficacy against bone metastases. Its in vivo activity can be measured recently by dosing of serum C telopeptide, produced by collagen destruction by the osteoclast. We report the first patient series, across several tumor types of the efficacy of denosumab in normalising serum CTX.

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