PCR- Negative Atypical PML-RARA Rearrangement in Pediatric Acute Promyelocytic Leukemia

Authors

  • Dan-Ping Huang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yi-Jun Chen Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Jie-Si Luo Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Shao-Qian Chen Department of Clinical Laboratory, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Jing Cheng Department of Clinical Laboratory, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yu Li Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Cong Liang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Li-Na Wang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Zhong Fan Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Xiao-Li Zhang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Xue-Qun Luo Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Li-Bin Huang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Yan-Lai Tang Department of Pediatrics, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

DOI:

https://doi.org/10.30683/1929-2279.2021.10.07

Keywords:

Acute promyelocytic leukemia, diagnosis, PML-RARA, FISH, t (15; 17)

Abstract

Acute promyelocytic leukemia (APL) is a special type of acute myeloid leukemia (AML), accounting for about 5% to 10% of children with AML. At the genetic level, APL is featured by a unique chromosome translocation t(15;17) which results in the PML-RARA gene fusion. Most patients can be diagnosed by traditional karyotype analysis, Fluorescence-In-Situ Hybridization (FISH), or Reverse Transcription-Polymerase Chain Reaction (RT-PCR). We report the case of a child with acute promyelocytic leukemia (APL) who had characteristic chromosome translocation t(15;17) and rare PML-RARA gene mutation. This patient had an excellent response to chemotherapy, suggesting that this mutation will not affect the treatment and prognosis of APL.

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Published

2021-12-14

How to Cite

Huang, D.-P., Chen, Y.-J., Luo, J.-S., Chen, S.-Q., Cheng, J., Li, Y., Liang, C., Wang, L.-N., Fan, Z., Zhang, X.-L., Luo, X.-Q., Huang, L.-B., & Tang, Y.-L. (2021). PCR- Negative Atypical PML-RARA Rearrangement in Pediatric Acute Promyelocytic Leukemia. Journal of Cancer Research Updates, 10, 51–55. https://doi.org/10.30683/1929-2279.2021.10.07

Issue

Vol. 10 (2021)

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