Metabolic Imbalance Associated Mitophagy in Tumor Cells: Genesis and Implications


  • Madhuri Chaurasia Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India
  • Shashank Misra Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India
  • Anant N. Bhatt Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India
  • Asmita Das Department of Biotechnology, Delhi Technological University, Delhi 110042, India
  • Bilikere Dwarakanath Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India
  • Kulbhushan Sharma Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India



Warburg, PARKIN, Oxidative stress, Metabolic Reprogramming, Calcium.


 Emerging knowledge supports the notion that metabolic reprogramming facilitates the progression of many cancers and in some it could be initiated by mutations in genes related to mitochondrial function. While dysfunctional mitochondria plays a pivotal role in driving metabolic reprogramming, mitophagy that recycles damaged mitochondria by selective and organized degradation appears to be vital for sustaining carcinogenesis. Although the potential of targeting mitophagy as a therapeutic strategy has still remained elusive, poor prognosis and therapeutic resistance of highly glycolytic tumors suggest that inhibitors of mitophagy could be potential adjuvant in radio- and chemotherapy of tumors. We briefly review the current status of knowledge on the interrelationship between mitophagy and metabolic reprogramming during carcinogenesis and examine mitophagy as a potential target for developing anticancer therapeutics and adjuvant.


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How to Cite

Madhuri Chaurasia, Shashank Misra, Anant N. Bhatt, Asmita Das, Bilikere Dwarakanath, & Kulbhushan Sharma. (2015). Metabolic Imbalance Associated Mitophagy in Tumor Cells: Genesis and Implications. Journal of Cancer Research Updates, 4(2),  95–107.