Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity

Chao-Zhan Lin; Ai-Zhi Wu; Ying Zhong; Yu-Mei Wang; Guang-Tian Peng; Xian-Jun Su; Bing-Xin Liu; Yun Deng; Chen-Chen Zhu; Cui-Xian Zhang

doi:10.6000/1929-2279.2015.04.02.3

Authors

Chao-Zhan Lin Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China
Ai-Zhi Wu School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Ying Zhong School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Yu-Mei Wang School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Guang-Tian Peng School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Xian-Jun Su School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Bing-Xin Liu School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Yun Deng School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China
Chen-Chen Zhu Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China
Cui-Xian Zhang School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

DOI:

https://doi.org/10.6000/1929-2279.2015.04.02.3

Keywords:

Psychotria serpens L., anti-cancer, flavonoids.

Abstract

In clinical, Psychotria serpens L. was often substitute for Caulis trachelospermi to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In order to search significant anti-cancer active leading compounds, sevenetin (5), rutin (6), kaempferol-3- flavonoids, quercetin (1), tamarixetin-3-O-rutinoside (2), quercetin 3-O-(2G-β-D-xylopyranosy-lrutinoside) (3), kaempferol (4), tamarixO- rutino- side (7) were isolated from P. serpens L., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS. 2-5 were the first isolated from genus Psychotria. All of compounds were the first isolated from P. serpens.

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