The Association of Obesity and Sistemic Arterial Hypertension with High-Grade Prostate Cancer: Our Experience

Abstract

 Introduction: Prostate cancer (PCa) is the first most frequently diagnosed cancer and the second most common cause of cancer death worldwide. We hypothesized that the presence of obesity and systemic arterial hypertension (SAH), separately and combined, would be associated with increased High-grade PCa risk, since the initial diagnosis.

Methods: We evaluated, in 133 patients undergoing prostate biopsy at our institution, the relationship between obesity (BMI 30) and SAH (systolic blood pressure 140, diastolic blood pressure 90) with High-grade PCa (Gleason score  7) at initial diagnosis. Men with urological surgery history, steroid therapy, chemotherapy, incomplete data, were excluded.

Results:Obesity was significantly associated (OR 2.25, p < 0.05) with High-grade PCa since the initial diagnosis. Particularly, obesity in association with SAH, was significantly linked to aggressive PCa pre-treatment (OR 2.84, p < 0.05). SAH was not associated in our study with aggressive PCa in non-obese men.

Conclusions:Obesity and SAH were significantly linked to aggressive PCa, at initial diagnosis, prior to hormonal or surgical therapy. Further larger studies should better clarify this relationship to support these associations and to evaluate future preventive and therapeutic strategies.