Patterns of Distant Failure and Second Primary Cancers in Patients with Oropharyngeal Squamous Cell Carcinoma: Implications for Surveillance Methodology

Authors

  • Edwin F. Crandley Department of Radiation Oncology, University of Virginia, P.O. Box 800383, Charlottesville, VA 22908, USA
  • David D. Wilson Department of Radiation Oncology, University of Virginia, P.O. Box 800383, Charlottesville, VA 22908, USA
  • Austin J. Sim Department of Radiation Oncology, University of Virginia, P.O. Box 800383, Charlottesville, VA 22908, USA
  • Neil Majithia Department of Radiation Oncology, University of Virginia, P.O. Box 800383, Charlottesville, VA 22908, USA
  • Edward B. Stelow Department of Pathology, University of Virginia, P.O. Box 800904, Charlottesville, VA 22908, USA
  • Mark J. Jameson Department of Otolaryngology – Head and Neck Surgery, University of Virginia, P.O. Box 800713, Charlottesville, VA 22908, USA
  • David C. Shonka Jr. Department of Otolaryngology – Head and Neck Surgery, University of Virginia, P.O. Box 800713, Charlottesville, VA 22908, USA
  • Asal S. Rahimi Department of Radiation Oncology, University of Texas – Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
  • Paul W. Read Department of Radiation Oncology, University of Virginia, P.O. Box 800383, Charlottesville, VA 22908, USA

DOI:

https://doi.org/10.6000/1929-2279.2014.03.03.5

Keywords:

Oropharynx cancer, surveillance, survivorship care, distant metastasis, second primary cancer.

Abstract

 Background: We analyzed the pattern of distant metastasis (DM) and secondary primary cancers (SPC) in patients with oropharyngeal squamous cell carcinoma (OPSCC) to develop surveillance guidelines. Methods: A retrospective review of 177 patients with OPSCC treated with intensity modulated radiation therapy ± chemotherapy between 2002 and 2012 was performed to characterize the rate, pattern, and timing of DM and SPC. Results: Sixteen patients (9.0%) developed DM and 9 patients (5.1%) developed a SPC. Overall, 24/177 patients (13.6%) developed a DM and/or SPC for a total of 27 events. 92.6% (25/27) of events were detectable on physical exam and/or chest CT. p16+ patients developed DM later than p16- tumors (23.4 months versus 8.7 months). Conclusions: Chest CT with physical examination detects the majority of DM and SPC in patients with OPSCC and would provide effective surveillance in these patients. A risk adapted surveillance strategy is proposed.

References

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Head and neck cancer clinical practice guidelines version 2.2013

Lung cancer screening clinical practice guidelines version 1.2014

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Published

2014-07-29

How to Cite

Edwin F. Crandley, David D. Wilson, Austin J. Sim, Neil Majithia, Edward B. Stelow, Mark J. Jameson, David C. Shonka Jr., Asal S. Rahimi, & Paul W. Read. (2014). Patterns of Distant Failure and Second Primary Cancers in Patients with Oropharyngeal Squamous Cell Carcinoma: Implications for Surveillance Methodology. Journal of Cancer Research Updates, 3(3),  151–161. https://doi.org/10.6000/1929-2279.2014.03.03.5

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