lincRNA HOTAIR as a Novel Promoter of Cancer Progression


  • Gregory Loewen Providence Regional Cancer Center, 105 W. 8th Avenue, Spokane, WA 99204, USA
  • Ying Zhuo Columbian Basin Hematology and Oncology, 7360 W. Deschutes, Kennewick, WA 99336, USA
  • Yan Zhuang Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
  • Janarthanan Jayawickramarajahand Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, LA 70118, USA
  • Bin Shan College of Medical Sciences, Washington State University Spokane, 412 E. Spokane Falls Boulevard, Spokane, WA 99202, USA



lincRNA, cancer, PRC2, EZH2, metastasis.


 Large intergenic non-coding RNAs (lincRNA) regulate development and disease via interactions with their protein partners. Expression of the lincRNA HOX transcript antisense RNA (HOTAIR) is elevated in a variety of malignancies and linked to metastasis and poor prognosis. HOTAIR promotes proliferation, invasion, and metastasis in the preclinical studies of cancer through modulation of chromatin modifying complexes. In the current review we discuss the molecular mechanisms of HOTAIR-mediated aggressive phenotypes of cancer, HOTAIRs potential in cancer intervention, and challenges in exploration of HOTAIR in cancer biology


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How to Cite

Gregory Loewen, Ying Zhuo, Yan Zhuang, Janarthanan Jayawickramarajahand, & Bin Shan. (2014). lincRNA HOTAIR as a Novel Promoter of Cancer Progression. Journal of Cancer Research Updates, 3(3),  134–140.