Anticancer Activity of Five Traditionally Used Medicinal Plants' Extracts

Authors

  • Ghazala H. Rizwani Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • De-Shen Wang Department of Pharmaceutical Science, College of Pharmacy and Health Sciences, St. John’s University, Queen, UY, USA
  • Mansoor Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • Amir Hassan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • Zheng-Rong Lai Department of Pharmaceutical Science, College of Pharmacy and Health Sciences, St. John’s University, Queen, UY, USA
  • Affnan Zahid Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • Najia Mansoor Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • Huma Sharif Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
  • Zhe-Sheng Chen Department of Pharmaceutical Science, College of Pharmacy and Health Sciences, St. John’s University, Queen, UY, USA
  • Zhi Shi Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China

DOI:

https://doi.org/10.6000/1929-2279.2014.03.02.4

Keywords:

Operculina turpethum, EtOH extract, Cell line cytotoxic activity, MTT bioassay.

Abstract

 Natural products play a critical role in cancer prevention and therapy today. There are numbers of anticancer agents from natural products used in the clinic.Fighting cancers with novel natural products, especially those extracted from plants, is a potential strategy to develop new anticancer drugs..In the following study, various extracts of well known medicinal plants named Holoptelea integrifolia (F), Operculina turpethum (R), Cardiospermem halicacabum L (S), Dilonix regia (F), Sesbania grandifora seed have been studied for evaluating their anticancer activity. Our data showed that the cytotoxic activity of Operculina turpethum (R) ethanolic extractwas relative high for all 6 cancer cell lines as compared to other extracts. The active compound and anticancer mechanism of these extracts are worth investigating in the future.

References

Kanchana A, Balakrishna M. Anti-cancer effect of saponins isolated from Solanum trilobatum leaf extract and induction of apoptosis in humanlarynx cancer cell lines. Int J Pharmacy Pharmaceut Sci 2011; 3: 356-64.

Kleinsmith LJ. Priniciples of Cancer Biology. 4th ed. Pearson Benjamin Cummings in San Francisco 2003; p. 312.

Cerutti AA. Oxidant stress and carcinogenesis. Eur J Clin Inves 1991; 21: 1-11. http://dx.doi.org/10.1111/j.1365-2362.1991.tb01350.x

Akinmoladum AC, Ibukun EO, Afor E, et al.Chemical constituents and antioxidant activity of Alstonia boonei. Afr J Biotechnol 2007; 6; 1197-201.

Halliwell B, Cutteridge JMC. Free redical in biology and medicine 3rd ed. Oxford University Press, London Chapter 3 1998.

Kirtikar KA, Basu BA. Indian Medicinal Plants,vol. 8 Periodical Expert’s Book Agency, New Delhi, India, 2nd ed, 2000.

Austin DF. Operculina turpethum (Convolvulaceae) as a medicinal plant in Asia. Economic Botany 1982; 3: 2265-9.

Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum agains 7,12-dimethylbenz(a)anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chem Biol Interact 2007; 168: 229-36. http://dx.doi.org/10.1016/j.cbi.2007.04.007

Khare AK, Srinivastava MC, Tewari JP, Puri JN, Singh S. A preliminary study of anti-inflammatory activity of Ipomoea turpethum (Nisoth). Indian Drugs 1982; 19: 2224-6.

Alam MJ, Alam I, Sharmin SA, Rahman MM, Aisuzzaman M, Alam MF. Micropropagation and antimicrobial activity of Operculina turpethum (syn. Ipomoea turpethumI), an endangered medicinal plants. Plant OMICS 2010; 3: 40-6.

Shankaraiah P, Srinvastava MC, Ravindra Babu P. Comparative antidiabetic activity of induced diabetic rats. Int Curr Pharmaceut J 2012; 1: 2272-8.

Bambhole VD, Jiddewar GG. Antiobesity effect of Iris versicolor and Holopetlea integrifolia in rats. Sachitra Ayurveda 1985; 37: 557-61.

Sandhar HK, Kaur M, Tiwari P, et al. Chemistry and medicinal properties of Holoptelea integrifolia. Int J Drug Dev Res 2011; 3: 6-11.

Misra G, Bhatnagar SC, Nigam SK. Constituents of Holoptelea integrifolia leaves and bark. Planta Medica 1974; 31: 232-4. http://dx.doi.org/10.1055/s-0028-1097519

George SK, Ragesh RS, Kumar S, Sulekha B, Balaram P. A polyherbal ayurvedic drug-indukantha gritha as an adjuvant to cancer chemotherapy via immunomodulation. Immunobiology 2008; 213: 641-49. http://dx.doi.org/10.1016/j.imbio.2008.02.004

Guo H, Wang D-S, Rizwani GH, et al. Antineoplastic activity of Holoptelea integrifolia (Roxb) Planch barck extract (in vitro). Pak J Pharmaceut Sci 2013; 26(6): 1151-56.

Delonix regia. Dpartment of Plant Sciences 2004; 16(1).

Khare CP. Indian Medicinal Plants. Springer International Edition, New York 2007; pp. 205-206.

Kirtikar B. “Indian MedicinalPlants”, 2nd edition, Bishen singh Mahendra Pal Singh Publishers 1991.

Outtara MB, et al. Antibacterial Potential and Antioxidant Activity of Polyphenols of Sesbaniagrandiflora. Curr Res J Biol Sci 2011; 3(4): 351-56.

Nadkarni AK, Nadkarni KM. Indian Materia Medica”, Popular Book Depot Originally by University of Michigan, 3rd ed., 1955.

Asad M, Ahmad T. Acacia nilotica leave extract and glyburidecomparison of fasting blood glucose, serum insulin, beta thromboglobulinlevels and platelet aggregation instreptozotocininduced diabetic rats. JPMA 2011; 61: 247.

Kumar D, Kumar K, Gupta J, Bishnoi N, Kumar S. A mini review on chemistry and biology of Holoptelea integrifolia roxb. Planch (Ulmaceae). Asian Pacific J Trop Biomed 2012; S1200-S1205

Vinod NV, Haridas M, Sadasivan C. Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against β-lactam resistant Staphylococcus aureus. Ind J Biochem Biophys 2010; 47: 53-55.

Khunkitti W, Fujimaki Y, Aoki Y. In vitro antifilarial activity of extract of the medicinal plant Cardiospermum halicacabum against Brugia pahangi. J Helminthol 2000; 74(3): 241-46.

Khan MSY, Aryan M, Javed K, Khan MH. Chemical examination of Cardiospermum halicacabum Linn. Ind Drugs 1990; 27: 257-58.

Aqil F, Ahmad I, Mehmood Z. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. Turk J Biol 2006; 30: 177-83.

Downloads

Published

2014-04-28

How to Cite

Ghazala H. Rizwani, De-Shen Wang, Mansoor Ahmed, Amir Hassan, Zheng-Rong Lai, Affnan Zahid, Najia Mansoor, Huma Sharif, Zhe-Sheng Chen, & Zhi Shi. (2014). Anticancer Activity of Five Traditionally Used Medicinal Plants’ Extracts. Journal of Cancer Research Updates, 3(2),  103–107. https://doi.org/10.6000/1929-2279.2014.03.02.4

Issue

Section

Articles

Similar Articles

You may also start an advanced similarity search for this article.