An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines

Authors

  • Christopher Krauss Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA
  • Chelsey Aurelius Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Kayla Johnston Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Victoria Bartlette Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Sherrita Gavin Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Jazmine Cuffee Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Satyendra Banerjee Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Sarah Wiseniewsky Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA
  • Santosh Mandal Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA
  • Hirendra Nath Banerjee Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

DOI:

https://doi.org/10.30683/1929-2279.2020.09.12

Keywords:

Rhenium Compounds, Uterine Cancer, Apoptosis, Tubulin, lymphocytes.

Abstract

Endometrial cancer of the uterus is highly malignant with an increase rate of morbidity and mortality in both childbearing age and postmenopausal women. Rhenium compounds have been shown to have therapeutic properties against various cancers both in vitro cell lines and in vivo animal models. In this in vitro study, we investigated the effects of a novel group of Rhenium ligands on a uterine cancer cell line. Our initial results showed that these compounds are cytotoxic, induces apoptosis and prevents tubulin polymerization in these uterine cancer cell lines, we also found these novel Rhenium compounds to be noncytocidal to healthy human blood lymphocyte cells, thus proving their safety and efficacy in future translational studies.

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Published

2020-04-06

How to Cite

Christopher Krauss, Chelsey Aurelius, Kayla Johnston, Victoria Bartlette, Sherrita Gavin, Jazmine Cuffee, Satyendra Banerjee, Sarah Wiseniewsky, Santosh Mandal, & Hirendra Nath Banerjee. (2020). An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines . Journal of Cancer Research Updates, 9(1), 102–106. https://doi.org/10.30683/1929-2279.2020.09.12

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Articles