Twice Operations for Parotid Metastasis of Nasopharyngeal Carcinoma Patient after Radical Intensity-Modulated Radiotherapy: A Case Report
DOI:
https://doi.org/10.6000/1929-2279.2017.06.04.2Keywords:
Nasopharyngeal carcinoma, Parotid lymph node metastasis, Prognosis, Intensity-modulated radiotherapy, Surgery.Abstract
The surgery treatment of parotid metastasis of nasopharyngeal carcinoma (NPC) after parotid-gland-sparing IMRT is rare report. We present such a case of NPC patient cT2N2M0 with parotid lymph node metastasis after parotid-gland-sparing IMRT patient who accepted the second operation after the first failure parotid section. This case reminded us that neck dissection added the whole parotid gland resection may be an appropriate method to treat this type of patients.
References
Wei WI, Sham JS. Nasopharyngeal carcinoma. The Lancet 2005; 365: 2041-54. https://doi.org/10.1016/S0140-6736(05)66698-6
Lee AW, Ma BB, Ng WT, Chan AT. Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective. J Clin Oncol 2015; 33: 3356-64. https://doi.org/10.1200/JCO.2015.60.9347
Ho FC, Tham IW, Earnest A, Lee KM, Lu JJ. Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer 2012; 12: 98. https://doi.org/10.1186/1471-2407-12-98
Wang X, Hu C, Ying H, et al. Patterns of lymph node metastasis from nasopharyngeal carcinoma based on the 2013 updated consensus guidelines for neck node levels. Radiol Oncol 2015; 115: 41-45. https://doi.org/10.1016/j.radonc.2015.02.017
Peng G, Wang T, Yang KY, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 2012; 104: 286-93. https://doi.org/10.1016/j.radonc.2012.08.013
Nutting CM, Morden JP, Harrington KJ, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. The Lancet Oncology 2011; 12: 127-36. https://doi.org/10.1016/S1470-2045(10)70290-4
Cannon DM, Lee NY. Recurrence in region of spared parotid gland after definitive intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol 2008; 70: 660. https://doi.org/10.1016/j.ijrobp.2007.09.018
Cao CN, Luo JW, Gao L, Xu GZ, Li SY, Xiao JP. Recurrence of nasopharyngeal carcinoma in the parotid region after definitive intensity-modulated radiotherapy. J Oral Maxillofac Surg 2013; 71: 1993-7. https://doi.org/10.1016/j.joms.2013.04.002
Lin DS, Jen YM, Lee JC, Liu SC, Lin YS. Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy. J Formos Med Assoc 2011; 110: 655-66. https://doi.org/10.1016/j.jfma.2011.08.009
Grégoire V, Ang K, Budach W, et al. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 2014; 110: 172-181. https://doi.org/10.1016/j.radonc.2013.10.010
Olsen SM, Moore EJ, Koch CA, Kasperbauer JL, Olsen KD. Oral cavity and oropharynx squamous cell carcinoma with metastasis to the parotid lymph nodes. Oral oncology 2011; 47: 142-4. https://doi.org/10.1016/j.oraloncology.2010.11.010
Xu Y, Chen X, Zhang M, et al. Prognostic effect of parotid area lymph node metastases after preliminary diagnosis ofnasopharyngeal carcinoma: propensity score matching study. Cancer Med 2017; 6:2213-21. https://doi.org/10.1002/cam4.1154
Wang HZ, Cao CN, Luo JW, et al. High-risk factors of parotid lymph node metastasis in nasopharyngeal carcinoma: a case-control study. Radiat Oncol 2016; 11: 113. https://doi.org/10.1186/s13014-016-0691-x
Cao CN, Luo JW, Gao L, et al. Clinical characteristics and patterns of failure in the parotid region after intensity-modulated radiotherapy for nasopharyngeal carcinoma. Oral Oncology 2013; 49: 611-4. https://doi.org/10.1016/j.oraloncology.2013.02.001