Molecular Genetic Study of the Allelic State of the Cell Cycle Genes (TP53, BRCA1) and Features of the Regulation of the Cytokine Cascade in Breast Cancer


  • S.K. Gantsev Scientific Research Institute of Oncology, Oncology Chair with Oncology, and Pathoanatomy courses of Further Professional Education, BaskortostanState University of Medicine, Russia
  • V.Y. Gorbunova Chair of Genetics, M. Akmully Baskortostan State Pedagogical University, Ufa, Russia
  • G.F. Galikeeva Chair of Genetics, M. Akmully Baskortostan State Pedagogical University, Ufa, Russia
  • E.V. Vorobyeva Chair of Genetics, M. Akmully Baskortostan State Pedagogical University, Ufa, Russia
  • E.M. Vasilyeva Chair of Genetics, M. Akmully Baskortostan State Pedagogical University, Ufa, Russia
  • R.A. Rustamhanov Scientific Research Institute of Oncology, Oncology Chair with Oncology, and Pathoanatomy courses of Further Professional Education, BaskortostanState University of Medicine, Russia



Breast cancer, tumor suppressor, cytokines, nucleotide substitutions, predisposition.


 This article contains the analysisof mutationsin genesthat regulate thecell cycle (TP53andBRCA1)andclassificationrelating totumor suppressor. Shown that the"risk"alleles of thesegenesmay contribute totumor development,butthe activation ofthe immune systemcytokine spectrumof patients canprevent theirdestructivedegeneration.The authors proposed apersonalizedapproach tothe study for thepreventionof possibleproliferative processes. This is confirmed byreversal of "risk" allelesstudied genesin tumors in operated patients with cytokine physiologically normal status.


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How to Cite

S.K. Gantsev, V.Y. Gorbunova, G.F. Galikeeva, E.V. Vorobyeva, E.M. Vasilyeva, & R.A. Rustamhanov. (2013). Molecular Genetic Study of the Allelic State of the Cell Cycle Genes (TP53, BRCA1) and Features of the Regulation of the Cytokine Cascade in Breast Cancer. Journal of Cancer Research Updates, 2(3),  211–219.