Alpha-Fetoprotein Producing Breast Cancer Cells: Case Report and Review of Literature


  • Asma Kassab Biochemistry laboratory Farhat Hached Hospital, Sousse, Tunisia
  • Awatef Msolly Biochemistry laboratory Farhat Hached Hospital, Sousse, Tunisia
  • Abdelhedi Miled Biochemistry laboratory Farhat Hached Hospital, Sousse, Tunisia
  • Olfa Gharbi Oncology service Farhat Hached Hospital, Sousse, Tunisia



Alpha-fetoprotein, Breast cancer, Colon cancer.


AbstractAim:In this paper we report a rare case of breast carcinoma followed by liver metastasis associated to alpha fetoprotein (AFP) secretion by tumor cells.

Methods:Carcino-embryonic antigen (CEA), carbohydrate antigen (CA) 15-3, serum AFP and AFP immunohistochemistry staining were detectedusing commercial kits in 44 year-old woman with breast cancer.

Results: CEA and CA 15-3 were within normal limits. AFP baseline was 14000 ng/l. There was no chronic hepatic viral disease. Biopsy revealed invasive carcinoma ductal cells. Histologic examination of the tumor showed invasive carcinoma, nuclear grade was 2, the tumour cells were negative for oestrogen and progesterone receptor positive for Her-2/neu. The immunohistochemistry stainig for AFP revealed positive reactivity. After chemotherapy, AFP level was within the normal rangeand abdominal ultrasonography showed a partial response evaluated at 50 %. The patient was in good condition at the time of our report (May 2013).

Conclusion:We presume that the increased serum AFP level is responsible for the cancer evolution with good prognosis for breast cancer and poor one for gastric cancer and colon cancer.


Gitlin D, Perricelli A, Gitlin GM. Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 1972; 32: 979-82.

Yin ZF, Wang CH. Research advances on alpha-fetoprotein physiological function and clinical potential. Ai Zheng 2003; 22: 108-11.

Mizejewski GJ, MacColl R. Alpha-fetoprotein growth inhibitory peptides: potential leads for cancer therapeutics. Mol Cancer Ther 2003; 2: 1243-55.

Mesfin FB, Andersen TT, Jacobson HI, Zhu S, Bennett JA. Development of a synthetic cyclized peptide derived from alpha-fetoprotein that prevents the growth of human breast cancer. J Pept Res 2001; 58: 246-56.

Parikh RR, Gildener-Leapman N, Narendran A, Lin HY, Lemanski N, Bennett JA, et al. Prevention of N-methyl-N-nitrosourea-induced breast cancer by alpha-fetoprotein (AFP)-derived peptide, a peptide derived from the active site of AFP. Clin Cancer Res 2005; 11: 8512-20.

Andersen TT, Georgekutty J, Defreest LA, Amaratunga G, Narendran A, Lemanski N, et al. An alpha-fetoprotein-derived peptide reduces the uterine hyperplasia and increases the antitumour effect of tamoxifen. Br J Cancer 2007; 97(3): 327-33.

Zhang Z, Yamashita H, Toyama T, Sugiura H, Ando Y, Mita K, et al. ATBF1-A Messenger RNA Expression Is Correlated with Better Prognosis in Breast Cancer. Clin Cancer Res 2005; 11: 193-8.

Sarui H, Nakayama T, Takeda N, Ishizuka T, Yasuda K. Alpha-fetoprotein-producing male breast cancer accompanied with hepatocellular carcinoma: assessment by lectin-affinity profile. Am J Med Sci 2001; 322: 369-72.

Bartram AH, Villano JL, Ferrera DM. Metastatic breast cancer mimicking hepatocellular carcinoma: differences in noninvasive guidelines. J Gastrointest Cancer 2010; 41(2): 145-8.

Mizejewski GJ. Mechanism of Cancer Growth Suppression of Alpha-Fetoprotein Derived Growth Inhibitory Peptides (GIP): Comparison of GIP-34 versus GIP-8 (AFPep). Updates and Prospects. Cancers 2011; 3: 2709-33.

Liu XY, Dong D, Sun P, Du J, Gu L, Ge YB. Expression and location of alpha-fetoprotein during rat colon development. World J Gastroenterol 2009; 14: 1738-43.

Chang YC, Nagasue N, Abe S, Taniura H, Kumar DD, Nakamura T. Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol 1992; 87: 21-5.

Chun H, Kwon SJ. Clinicopathological characteristics of alpha-fetoprotein-producing gastric cancer. J Gastric Cancer 2011; 11(1): 23-30.

Liu X, Cheng Y, Sheng W, Lu H, Xu Y, Long Z, et al. Clinicopathologic features and prognostic factors in alpha-fetoprotein-producing gastric cancers: analysis of 104 cases. J Surg Oncol 2010; 102(3): 249-55.

Marx GM, Boyce A, Goldstein D. Elevated alpha-foetoprotein and hepatic metastases--it's not always what it seems. Ann Oncol 2002; 13: 167-9.

Shibata Y, Sato K, Kodama M, Nanjyo H. Alpha-fetoprotein-producing early gastric cancer of the remnant stomach: report of a case. Surg Today 2007; 37: 95-9.

Moritani M, Fujimitsu Y, Shinohara M, Niido T, Tsuchida A, Aoki T, Koyanagi Y. A case of AFP producing early gastric cancer successfully treated with small dose CDDP and 5-FU (PF) therapy. Gan To Kagaku Ryoho 2001; 2813: 2079-82.

Yachida S, Fukushima N, Nakanishi Y, Akasu T, Kitamura H, Sakamoto M, Shimoda T. Alpha-fetoprotein-producing carcinoma of the colon: report of a case and review of the literature. Dis Colon Rectum 2003; 46: 826-31.

Liu XY, Dong D, Sun P, Du J, Gu L, Ge YB. Expression and location of alpha-fetoprotein during rat colon development. World J Gastroenterol 2009; 15(14): 1738-43.

Hiraoka A, Nakahara H, Kawasaki H, Shimizu Y, Hidaka S, Imai Y, et al. Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3). Intern Med 2012; 51(11): 1341-9.

Brown JA, Roberts CS. Elevated serum alpha-fetoprotein levels in primary gallbladder carcinoma without hepatic involvement. Cancer 1992; 70(7): 1838-40.<1838::AID-CNCR2820700705>3.0.CO;2-G




How to Cite

Asma Kassab, Awatef Msolly, Abdelhedi Miled, & Olfa Gharbi. (2013). Alpha-Fetoprotein Producing Breast Cancer Cells: Case Report and Review of Literature . Journal of Cancer Research Updates, 2(3),  140–143.