Present and Emerging Targeted Therapy for Metastatic Breast Cancer

Authors

  • Vito Lorusso Medical Oncology Istituto Oncologico IRCCS Bari, Italy
  • Ilaria Marech Medical Oncology Istituto Oncologico IRCCS Bari, Italy
  • Marianna Giampaglia Medical Oncology Unit, Vito Fazzi Hospital, Lecce, Italy
  • Andrea Tinelli Gynecologic Unit, Vito Fazzi Hospital, Lecce, Italy
  • Vincenzo Emanuele Chiuri Medical Oncology Unit, Vito Fazzi Hospital, Lecce, Italy

DOI:

https://doi.org/10.6000/1929-2279.2012.01.01.14

Keywords:

Breast cancer, targeted therapy, EGFR, HER2, VEGF, mTOR inhibitors, PARP-1 inhibitors.

Abstract

 Breast carcinoma is a complex and heterogeneous disease and several different molecular alterations are involved in its pathogenesis and progression. Different growth factor receptor-driven signaling pathways sustain the growth and survival of breast cancer cells. Actually, three targeted agents are available for the treatment of breast cancer: trastuzumab, a monoclonal antibody directed against the human epidermal growth factor receptor-2 (HER2); lapatinib, an oral available dual tyrosine-kinase inhibitor of the human epidermal growth factor receptor-1 (HER1, EGFR) and HER2; bevacizumab, a monoclonal antibody directed against the vascular endothelial growth factor (VEGF). All these agents demonstrated to be synergistic with chemotherapy. In addition, recently concluded clinical trials suggest that signaling inhibitors can prevent or overcome resistance to endocrine therapy in estrogen receptor positive (ER+) breast cancer. Moreover, several other targeted drugs are under investigation in clinical trials. The aim of this review is to give a synthetic but complete picture of various targeted agents for breast cancer therapy that are under clinical trials or currently available in clinical practice.

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2012-01-28

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Vito Lorusso, Ilaria Marech, Marianna Giampaglia, Andrea Tinelli, & Vincenzo Emanuele Chiuri. (2012). Present and Emerging Targeted Therapy for Metastatic Breast Cancer . Journal of Cancer Research Updates, 1(1),  94–101. https://doi.org/10.6000/1929-2279.2012.01.01.14

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