Does Tumour Biological Behaviour Influence Prognosis More than Diagnostic Delay in Oral Cancer?

Authors

  • Juan Manuel Seoane-Romero Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain
  • Pablo Ignacio Varela-Centelles Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain
  • Pedro Diz-Dios Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain
  • Isabel Ramos-Barbosa Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain
  • Javier Fernández Feijoo Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain
  • Juan Seoane Grupo de Investigación en Odontología Médico-Quirúrgica (OMEQUI), School of Medicine and Dentistry, Santiago de Compostela University, Spain

DOI:

https://doi.org/10.6000/1929-2279.2012.01.01.05

Keywords:

Mouth neoplasms, prognosis, delayed diagnosis, biological behaviour, squamous cell carcinoma.

Abstract

 Worldwide, oral cancer has one of the lowest survival rates (lethal disease for over 50% of cases diagnosed annually) and remains unaffected despite recent therapeutic advances.

Unfortunately, almost half of the oral cancers are diagnosed at stages III or IV, probably due to delays in reaching a definitive diagnosis. Many preventive approaches (secondary prevention) have been designed assuming the logical hypothesis that the longer the diagnostic delay, the more advanced the cancer and the worse the prognosis. However, a number of studies failed to prove this association or even found an inverse relationship.

We hypothesize that tumour's biological heterogeneity in terms of aggressiveness may explain shorter delays linked to advanced stages and bad prognosis. The assumption of this hypothesis would entail favouring oral cancer and precancer screening strategies at the preclinical stage of the disease, and therefore strategies of opportunistic screening for oral cancer and precancer on asymptomatic at risk population should be reinforced.

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Published

2012-01-28

How to Cite

Juan Manuel Seoane-Romero, Pablo Ignacio Varela-Centelles, Pedro Diz-Dios, Isabel Ramos-Barbosa, Javier Fernández Feijoo, & Juan Seoane. (2012). Does Tumour Biological Behaviour Influence Prognosis More than Diagnostic Delay in Oral Cancer? . Journal of Cancer Research Updates, 1(1),  22–27. https://doi.org/10.6000/1929-2279.2012.01.01.05

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