A Review of the Expression of Genes Involved in Sex Steroid Hormone Metabolism in Prostate Tissue: A Need for Epigenetic Information

Authors

  • Jamie Ritchey University of South Carolina, Department of Epidemiology and Biostatistics, 800 Sumter Street, Columbia, SC, 29208
  • Wilfried Karmaus University of South Carolina, Department of Epidemiology and Biostatistics, 800 Sumter Street, Columbia, SC, 29208
  • Tara Sabo-Attwood University of Florida, Department of Environmental and Global Health, P.O. Box 100188, HPNP Building, Room 2150, Gainesville, FL 32610, USA
  • Susan E. Steck University of South Carolina, Department of Epidemiology and Biostatistics, 800 Sumter Street, Columbia, SC, 29208
  • Hongmei Zhang University of South Carolina, Department of Epidemiology and Biostatistics, 800 Sumter Street, Columbia, SC, 29208

DOI:

https://doi.org/10.6000/1927-7229.2013.02.03.3

Keywords:

Prostate tissue, cancer, sex steroid hormones, methylation, GSTP1

Abstract

 There is strong clinical and laboratory evidence indicating that sex steroid hormones are important to the development and progression of prostate cancer, yet results from epidemiologic research conflicts. Examining gene expression in the sex steroid hormone pathway may uncover differences between cancerous and non-cancerous prostate tissues, yet our review using a pathway-oriented approach indicates that there is limited consistency across results, with the exception of GSTP1 found in the estrogen pathway, which was under-expressed in cancerous prostate tissue. This agrees with past studies that reported GSTP1 is methylated in prostate cancer. With new cost-effective technology, we can screen for epigenetic markers, like methylation, which can be applied in epidemiological studies. A clearer understanding of gene expression and epigenetic mechanisms in prostate cancer may contribute to improving prevention, diagnosis, and treatment.

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2013-08-28

How to Cite

Jamie Ritchey, Wilfried Karmaus, Tara Sabo-Attwood, Susan E. Steck, & Hongmei Zhang. (2013). A Review of the Expression of Genes Involved in Sex Steroid Hormone Metabolism in Prostate Tissue: A Need for Epigenetic Information. Journal of Analytical Oncology, 2(3),  142–150. https://doi.org/10.6000/1927-7229.2013.02.03.3

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