A Novel Method to Radiolabel Stealth Liposome through 1,2- dimyristoyl-sn-glycero-3-phosphoethanolamine-N-DTPA with 99mTc and Biological Evaluation
DOI:
https://doi.org/10.6000/1927-7229.2013.02.01.1Keywords:
Liposome, nanomedicine, diagnostic oncologyAbstract
Purpose: To study surface technetium labeling of stealth DTPA-Liposomeand to evaluate its potential as a molecular imaging tracer for both normal and melanoma-bearing mice.
The radiolabeling yield of liposomes was greater than 90%and showed good chemical and biological stability. Biodistribution studies in normal mice showed blood clearance with hepatic and renal depuration. Melanoma-bearing mice showed a similar pattern of biodistribution with high tumor uptake allowing tumor imaging.
The developed method of surface radiolabeled DTPA-PEG-Liposomes with 99mTc was effective and stable in vivo.
References
Ferrari M. Review. Nat Rev Cancer 2005; 5(3): 161-71. http://dx.doi.org/10.1038/nrc1566
Torchilin V. Targeted Pharmaceutical Nanocarriers for Cancer Therapy and Imaging. AAPS J 2007; 9: 128-47. http://dx.doi.org/10.1208/aapsj0902015
Maldelmont CG, Lesieur S, Ollivon M. Characterization of loaded liposome by size exclusion chromatography. J Biochem Biophys Methods 2003; 56: 189-17. http://dx.doi.org/10.1016/S0165-022X(03)00059-9
Jain R, Dandekar P, Patravale V. Diagnostic nanocarriers for sentinel lymphnode imaging. J Control Release 2009; 138: 90-102. http://dx.doi.org/10.1016/j.jconrel.2009.05.010
Taki J, Sumiya H, Asada N, Ueda Y, Tsuchiya H, Tonami N. Assessment of p-glycoprotein in patients with malignant bone and solft-tissue using technetium-99m-MIBI scintigraphy. J Nucl Med 1998; 39: 1179-84.
Boerman OC, Laverman P, Oyen WJG, Corstens FHM, Storm G. Radiolabeled Liposomes scintigraphic Imaging. Progress Lipid Research 2000; 39: 461-75. http://dx.doi.org/10.1016/S0163-7827(00)00013-8
Cornelis Sikkink JJM, Reijnen M, Leverman P, Oyen JG, Van Goor H. Tc-99m-PEG –Liposome by Hyaluronate in Rats With Fecal Peritonitis. J Surg Res 2008; 1-6.
Fenske DB, Maurer N, Cullis PR. Encapsulation of weakly- basic drugs, antisene oligonucleotides and plasmid DNA within large unilamellar vesicles for drug delivery applications. In: Torchilin V, Weissig W Liposomes,Oxford University press/Oxford New York 2003; pp. 167-188.
Koukouarakis MI, Koukouarki S, Fezoulidis I, Kelekis N, Kyrias G, Archimandritis S, et al. High intratumoral acumulation of stealth doxorubicin (Caelyx®) in glyoblastomas and in metastatic brain tumors. Br J Cancer 2000; 83: 1281-88. http://dx.doi.org/10.1054/bjoc.2000.1459
Harrington K, Mohammadtaghi S, Uster P, Vile R, Stewart S. Effective Targeting of Solid Tumors in Patients with Loclly advanced Cancers by Radiolabeled Pegylated Liposome. J Clin Canc Res 2001; l7: 243-54.
Laverman P, Dams E, Oyen W, Storm G, Koenders E, Prevost R, et al. A Novel Method to Label Liposomes with 99mTc by the Hydrazino Nicotinyl Derivative. J Nucl Med 1999; 40: 192-97.
Dams E, Oyen W, Boerman O, Storm G, Laverman P, Kok P, et al. 99mTc-PEG Liposomes for the Scintigraphic Detection of Infection and Inflammation: Clinical Evaluation. J Nucl Med 2000; 41: 622-30.
Laverman P, Zalipsky S, Oyen W, Dams E, Storm G, Mullah N, et al. Improved Imaging of Infections by Avidin-Induced Clearance of 99mTc-Biotin-PEG Liposomes. J Nucl Med 2000; 41: 912-18.
Papahadjopoulos D, Allen TM, Gabizon A, Mayhew E, Huang SK, Lee KD, et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci USA 1991; 88: 11460-4. http://dx.doi.org/10.1073/pnas.88.24.11460
Irma AJM, Bakker-Woudenberg. Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious foci. Intern J Antimicrob Agent 2002; 19: 299-11. http://dx.doi.org/10.1016/S0924-8579(02)00021-3
Raymond M, Schiffelers R, Gjini E, Fens M, Storm G. Targeting Tumor Angiogenesis Using Liposomes. In: Gregory Gregoriadis. Liposome Technology Third Edition Volume III, United Kingdom 2007; pp. 113-122.
Belhaj-Tayeb H, Briane D, Vergote J, Cao A, Moretti J. In vitro and in vivo study of 99mTc-MIBI enacpsulated in PEG-liposome: a promising radiotracer for tumor imaging. Eur J Nucl Molec Imaging 2003; 30: 502-509. http://dx.doi.org/10.1007/s00259-002-1038-4
Tiwari SB, Mansoor A. A Review of Nanocarrier-Based CNS Delivery Systems. Curr Drug Deliv 2006; 3: 219-32. http://dx.doi.org/10.2174/156720106776359230
Ganta S, Devalapally H, Shahiwala A, Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Cont Release 2008; 126(3): 187-204. http://dx.doi.org/10.1016/j.jconrel.2007.12.017
Richardson VJ, Jeyasingh K, Jewkes RF, Ryman BE. Properties of
Goyal P, Goyal K, Kumar SG, Singh A, Katare OMP, Mishra DN. Liposomal drug delivery systems. Clinic Appl Acta Pharm 2005; 55: 1-25.
Phillips W. Delivery of gamma-imaging agents by liposomes. Adv Drug Deliv Rev 1999; 37: 13-32. http://dx.doi.org/10.1016/S0169-409X(98)00108-2
Laverman P, Carstens M, Boerman O, Dams E, Oyen W, Rooijen N, et al. Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes upon Repeated Injection. JPET 2001; 298: 607-12.
Storm G, Belliot SO, Deamen T, Lasic DD. Surface modification of nanoparticules to oppose up take by the mononuclear phagocyte system. Adv Drug Del Rev 1995; 17: 31-48. http://dx.doi.org/10.1016/0169-409X(95)00039-A
Hwang KJ, Luk K, Beaumier P. Hepatic uptake and degradation of unilamellar sphingomyelin/cholesterol liposomes: A kinetic study. Proc Nati Acad Sci USA 1980; 77: 4030-34. http://dx.doi.org/10.1073/pnas.77.7.4030
Harashima H, Kume Y, Yamane C, Kiwada H. Kinetic modeling of liposome degradation in blood circulation. Bioph Drug Dispo 1993; 14: 265-70. http://dx.doi.org/10.1002/bdd.2510140309
Ishida O, Maruyama K, Sasaki K, Iwatsuru M. Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumor-bearing mice. Int J Pharma 1999; 190: 49-56. http://dx.doi.org/10.1016/S0378-5173(99)00256-2
Leunig M, Huang SK, Berk DA, Papahadjopoulos D. Mirovascular Permeability and Interstitial Penetration of Sterically Stabilized (Stealth) Liposomes in a Human Tumor Xenograft. Cancer Res 1994; 54: 3352.
Hamoudeha M, Kamleh M, Diab R, Fessi H. Radionuclides delivery systems for nuclear imaging and radiotherapy of cáncer. Adv Drug Deliv Rev 2008; 60: 1329-46. http://dx.doi.org/10.1016/j.addr.2008.04.013
Laverman P, Brouwers A, Dams E, Oyen W, Storm G, Rooijen NV, et al. Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose. J Pharma Exp Ther 2000; 293: 996-1001.