Comparison of Prostate Specific Antigen and Prostate Specific Antigen Density for Predicting the Degree of Gleason Score of Prostate Cancer
Keywords:Prostate specific antigen, Prostate cancer, Gleason’s score, Tumor Grading, Gleason Grading
Introduction: In this study we evaluate the relationship of PSA and PSAD with the degree of Gleason score of prostate cancer in transrectal ultrasound guided biopsy specimens.
Methods: From March 2003 to October 2009, 1025 transractal ultrasound guided biopsies were performed in our hospital. PSA was measured by monoclonal antibody method and PSAD was calculated. The Gleason grade of the detected tumors in the biopsy specimens was classified as low, moderate and high grade. Data were analyzed by SPSS software.
Results: 292 patients were diagnosed to have prostate adenocarcinoma. There was an acceptable correlation between PSA (P=0.001) and PSAD of the specimens (P = 0.013) with Gleason grades. PSA level showed a statistically significant difference between the low and high grade groups (P=0.005) and the intermediate and high grade groups (p=0.014). A statistically significant difference of PSAD level was seen only between the low and high grade (P=0.006) groups
Conclusions: PSA and PSAD are both effective diagnostic tools for detection of prostate cancer; PSA level has a valuable role in predicting Gleason pattern higher than 7/10 and it can be the predictor of advanced pathological features but PSAD is effective in prediction of Gleason pattern lower than 5/10.
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