Buschke Löwenstein Tumor of the Right Lower Abdominal Wall: Case Report and Review of the Literature
DOI:
https://doi.org/10.6000/1927-7229.2015.04.01.6Keywords:
Buschke-Löwenstein tumor, Giant condyloma acuminatum, surgical resection, neoadjuvant therapy, squamous cell carcinomaAbstract
Buschke-Löwenstein tumor (BLT), known as giant condyloma acuminatum (GCA), is a very rare disease that typically appears as a penile lesion but can although appear in the anogenital region, bladder, vulva, scrotum and sacrococcygeal area as well. Despite of its histologically benign signs, a high recurrence rate, invasiveness and destructive growth characterizes this rare disease as clinically malignant. Malignant transformation into verrucous carcinoma (VC) and squamous-cell carcinoma (SCC) have been described as well. Many treatment modalities inclusive neoadjuvant radio-and chemotherapy and topical treatment have been reported but due to lack of controlled studies no treatment can be recommended. We present a case of Buschke-Löwenstein tumor involving the right lower abdominal wall of the colostomy region at a 71 years old male. To our knowledge, we first describe a case report of GCA involving abdominal wall at the colostomy region, successfully treated by wide radical excision and plastic reconstruction.
References
Buschke A, Löwenstein L. Über karzinomähnlich Condylomata acuminata des Penis. KlinWochenschr 1925; 4: 1726-1728. http://dx.doi.org/10.1007/BF01728480
Dawson DF, Duckworth SK, Bernhardt H, Young JM. Giant condyloma and verrucous carcinoma of he genital area. Arch Pathol 1965; 79: 225-231.
Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma accuminatum ( Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum 1994; 37(9): 950-957. http://dx.doi.org/10.1007/BF02052606
Creasman C, Haas PA, Fox TA Jr, Balasz M. Malignant transformation of anorectal giant condyloma accuminatum (Buschke-Löwenstein Tumor). Dis Colon Rectum 1989; 32: 481-487. http://dx.doi.org/10.1007/BF02554502
Trombetta U, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and managemnet. Dis Colon Rectum 2001; 44: 1878-1886. http://dx.doi.org/10.1007/BF02234473
Yakan S, Cengiz F, Telciler KE, Zu M, Denecli AG. Rectal involvement of reccurent Buschke-Lowenstein Tumor causing subileus: a case report. Gastroenterology Research 2001; 4(4): 177-179.
Norris CS. Giant condyloma acuminatum (Buschke-Lowenstein tumor) involving a pilonidal sinus: a case report and review of a literature. J Surg Oncol 1983; 22(1): 47-50. http://dx.doi.org/10.1002/jso.2930220113
Wiedemann A, Diekmann WP, Holtmann G, Kracht H. Report of a case with giant condyloma (Buschke-Löwenstein tumor) localized in the bladder. J Urol 1995; 153(4): 1222-4. http://dx.doi.org/10.1016/S0022-5347(01)67559-1
Rhea WG Jr, Bourgeois BM, Sewell DR. Condyloma acuminata: a fatal disease? Am.Surg 1998; 64(11): 1082-7.
Mentes O, Akbulut M, Bagci M. Verrucous carcinoma (Buschke –Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case. Langenbecks Arch Surg 2008; 393(1): 111-4. http://dx.doi.org/10.1007/s00423-007-0209-y
Piepkorn M, Kumasaka B, Krieger JN, Burmer GC. Development of human papillomavirus-associated Buschke-Löwenstein penile carcinoma during cyclosporine therapy for generalized pustular psoriasis. J Am Acad Dermatol 1993; 29(2 Pt 2): 321-5. http://dx.doi.org/10.1016/0190-9622(93)70186-W
Renzi A, Brusciano L, Giordano P, Rosseti G, Izzo D, Del Genio A. Buschke Lowenstein Tumor successful treatment by surgical excision alone: a case report. Chir Ital 2004; 56: 297-300.
Chao MWT, Gibbs P. Squamous cell carcinoma arising in a giant accuminatum (Buschke-Löwenstein tumor). Asian J Surg 2005; 28: 238-240. http://dx.doi.org/10.1016/S1015-9584(09)60352-3
Pacha O, Pickett MM, Hebert AA. Scrotal Buscke-Lowenstein tumor in an AIDS Patient Sex.Transm Dis 2012; 39(3): 236-7. http://dx.doi.org/10.1097/OLQ.0b013e318244ac66
Mstrangelo M, Mobiglia A, Cassoni P, Castellano I, Maass J, Martina MC, Bello M, Mussa A. Verrucous carcinoma of the anus or Buschke-Lowenstein tumor of the anus: staging and treatment.Report of 3 cases. Suppl Tumori 2005; May-Jun; 4(3): S29-30.
Wietfeldt ED, Thiele J. Malignancies of the anal margin and perianal skin. Clin Colon Rectal Surg 2009; 22: 127-135. http://dx.doi.org/10.1055/s-0029-1223845
Prasad ML, Abcarian H. Malignant potential of perianal condyloma acuminatum. Dis Colon Rectum 1980; 23: 191-7. http://dx.doi.org/10.1007/BF02587626
Abcarian H, Smith D, Sharon N. The immunotherapy of anal condyloma acuminatum. Dis Colon Rectum 1976; 19: 237-244. http://dx.doi.org/10.1007/BF02590909
Efthaiha MS, Amshel Al, Shonberg IL, Batshon B. Giant and reccurent condyloma acuminatum appraisla of immunotherapy. Dis Colon Rectum 1982; 25: 136-138. http://dx.doi.org/10.1007/BF02553258
Hyacinthe M, Karl R, Coppola D, Goodgame T, Redwood W, Goldenfarb P, Ohori NP, Marcet J. Squamous cell carcinoma of pelvis in a giant condyloma acuminatum: use of neoadjuvant chemoradiation and surgical rsection: report of a case. Dis Colon Rectum 1998; 41: 1450-1453. http://dx.doi.org/10.1007/BF02237065
Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J. Combined surgery and chemoradiation as a treatment for the Buschke-Lowenstein tumour. Surgeon 2006; 4: 378-383. http://dx.doi.org/10.1016/S1479-666X(06)80114-9
Yoshimura Y, Mishima K, Obara S, Nariai Y, Yoshimura H, Mikami T. Treatment modalities for oral verrucous carcinomas and their outcomes: contribution of radiotherapy and chemotherapy. Int J Clin Oncol 2001; 6: 192-200. http://dx.doi.org/10.1007/PL00012104
Schwade JG, Wara WM, Dedo HH, Phillips TL. Radiotherapy for verrucous carcinoma. Radiology 1976; 120: 677-679. http://dx.doi.org/10.1148/120.3.677
Sobrado CW, Mester N, Nadalin W, Nahas SC, Bocchini SF, Habr-Gama A . Radiation-induced total regression of a highly recurrent giant perianal condyloma: report of a case. Dis Colon Rectum 2000; 43: 257-260. http://dx.doi.org/10.1007/BF02236991
Schwartz RA. Verrucous carcinoma of the skin and mucosa.J Am Acad Dermatolo 1995; 32: 1-21. http://dx.doi.org/10.1016/0190-9622(95)90177-9
Bertram P, Treutner KH, Rübben A, Hauptmann S, Schumpelick V. Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-Löwenstein tumor). Langenbecks Arch Chir 1995; 380(2): 115-8. http://dx.doi.org/10.1007/BF00186418