Amelanotic Melanoma of the Root of the Tongue in A Canine Patient Treated by Electrochemotherapy
DOI:
https://doi.org/10.6000/1927-7229.2014.03.04.6Keywords:
Amelanotic melanoma, electroporation, cancer, ECT, dog.Abstract
Background: Electrochemotherapy is a novel tumor treatment routinely used for cutaneous and subcutaneous tumors in human patients in the European Union since 2006. Here we used it to treat an amelanotic melanoma of the root of the tongue in a canine patient.
Case Presentation: The patient was a 9 year-old, female, Golden Retriever, dehydrated, cachectic and in a bad general condition due to the difficulty in eating and drinking provoked by the tumor. The procedure was performed with general anesthesia, with intravenous administration of bleomycin, and went uneventful. The only adverse effect was an important swelling of the tongue which lasted 2 days and was controlled with non-steroidal anti-inflammatory drugs.
Results and Conclusion: A good local control of the disease was achieved with a 83% reduction of the tumor mass, at day 21 after a single treatment. On the 33rd day the patient died after a digestive hemorrhage not related to the treatment. Electrochemotherapy was found a good approach to locally control the disease. The swelling of the tongue was an important side effect which has to be taken into account when treating this organ, and should be controlled with medication.
References
Ramos-Vara JA, Beissenherz ME, Miller MA, Johnson GC, Pace LW, Fard A et al. Retrospective Study of 338 Canine Oral Melanomas with Clinical, Histologic, and Immunohistochemical Review of 129 Cases. Vet Pathol 2000; 37: 597-608. http://dx.doi.org/10.1354/vp.37-6-597
Teixeira TF, da Silva TC, Cogliati B, Nagamine MK, Dagli MLZ. Retrospective study of melanocytic neoplasms in dogs and cats. Braz J Vet Pathol 2010; 3: 100-104.
Ballinari U, Schiller I, Schroff-Ballinari A, Mazzi M. Case report: oral malignant melanoma in an 11-month-old Dobermann. Schweiz Arch Tierheilkd 1998; 140:110-3.
Veena P, Kokila S, SureshKumar RV, Sankar P, Dhanalakshmi N. Malignant Melanoma in a Dog - A Case report. Vet World 2012; 5: 431-432. http://dx.doi.org/10.5455/vetworld.2012.431-432
Withrow SJ, Vail DM. Specific Malignancies in the small animal patient. Withrow and MacEwen’s Small Animal Clinical Oncology. 4th ed. St. Louis: Saunders Elsevier; 2007.
Bateman KE, Catton PA, Pennock PW, Kruth SA. Radiation Therapy for the Treatment of Canine Oral Melanoma. J Vet Intern Med 1994; 8: 267-272. http://dx.doi.org/10.1111/j.1939-1676.1994.tb03231.x
Modiano JF, Ritt MG, Wojcieszyn J. The Molecular Basis of Canine Melanoma: Pathogenesis and Trends in Diagnosis and Therapy. J Vet Intern Med 1999; 13:163-174. http://dx.doi.org/10.1111/j.1939-1676.1999.tb02173.x
Bergma PJ. Canine Oral Melanoma. Clin Tech Small Anim Pract 2007; 22: 55-60. http://dx.doi.org/10.1053/j.ctsap.2007.03.004
Finocchiaro LME, Glikin GC. Cytokine-enhanced vaccine and suicide gene therapy as surgery adjuvant treatments for spontaneous canine melanoma. Cancer Gene Ther 2008; 15:267-276. http://dx.doi.org/10.1038/sj.cgt.7701096
Mir LM. Bases and rationale of the electrochemotherapy. Eur J Cancer Suppl 2006; 4:38-44. http://dx.doi.org/10.1016/j.ejcsup.2006.08.005
Marty M, Sersa G, Garbay J, Gehl J, Collins C, Snoj M et al. Electrochemotherapy - An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 2006; 4:3-13. http://dx.doi.org/10.1016/j.ejcsup.2006.08.002
Mir LM, Devauchelle P, Quintin-Colonna F, Delisle F, Doliger S, Fradelizi D et al. First clinical trial of cat soft-tissue sarcomas treatment by electrochemotherapy. Brit J Cancer 1997; 76:1617-1622. http://dx.doi.org/10.1038/bjc.1997.606
Cemazar M, Tamzali Y, Sersa G, Tozon N, Mir LM, Miklavcic D et al. Electrochemotherapy in Veterinary Oncology. J Vet Intern Med 2008; 22: 826-831. http://dx.doi.org/10.1111/j.1939-1676.2008.0117.x
Merck Manuals. The Merck Veterinary Manual. Weight to body surface area conversion. Whitehouse Station, NJ, USA, Inc.; c2009-2014 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., All rights reserved.
[updated 2012 march; cited 2014 oct 19] Available from URL: http://www.merckvetmanual.com/mvm/htm/bc/tref9.htm.
WHO Handbook for Reporting Results of Cancer Treatment. WHO Offset Publications 1979; 48:22-27.
Fleischman RW, Baker JR, Thompson GR, Schaeppi UH, Illievski VR, Cooney DA et al. Bleomycin-induced interstitial pneumonia in dogs. Thorax 1971; 26: 675-682. http://dx.doi.org/10.1136/thx.26.6.675
Spugnini EP, Dragonetti E, Vincenzi B, Onori N, Citro G, Bladi A. Pulse-mediated chemotherapy enhances local controland survival in a spontaneous canine model of primary mucosal melanoma. Melanoma Res 2006; 16: 23-27. http://dx.doi.org/10.1097/01.cmr.0000195702.73192.a0
Quaglino P, Mortera C, Osella-Abate S, Barberis M, Illengo M, Rissone M et al. Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases. Ann Surg Oncol 2008; 15: 2215-22. http://dx.doi.org/10.1245/s10434-008-9976-0
Breton M, Mir LM. Microsecond and nanosecond electric pulses in cancer treatments. Bioelectromagnetics 2011. http://dx.doi.org/10.1002/bem.20692
Campana LG, Mocellin S, Basso M, Puccetti O, De Salvo GL, Chiarion-Sileni V et al. Bleomycin-based electrochemotherapy: clinical outcome from a single institution's experience with 52 patients. Ann Surg Oncol 2009; 16: 191-9. http://dx.doi.org/10.1245/s10434-008-0204-8
Testori A, Rossi CR, Tosti G. Utility of electrochemotherapy in melanoma treatment. Curr Opin Oncol 2012; 24:155-61. http://dx.doi.org/10.1097/CCO.0b013e32834fcaa8
Silve A, Mir LM. Cell electropermeabilisation and small molecules cellular uptake: the electrochemotherapy concept. In: Kee S, Lee E, Gehl J editors. Electroporation in Science and Medicine. 1st ed. New York: Springer 2010; p. 69-82.
