Serum Biomarkers Study and the Establishment of Diagnostic Models for Hepatitids B-Related HCC
Keywords:Primary hepatocellular carcinoma, des-γ-carboxy-prothrombin, alpha fetoprotein, golgi protein 73, diagnostic value: support vector machine.
China's HCC accounts for 90% of HBV related HCC. Early detection, diagnosis and treatment are the key to effective control of HCC. By measuring the levels of expression of AFP, DCP and GP73 in the serum of HBV-related HCC patients, the diagnostic value of single and combined detection of the above indicators in HBV-related HCC shall be discussed, and the mathematical model of differential diagnosis by SVM shall be established to provide reference for the diagnosis of HBV-related HCC. A total of 301 patients and healthy persons from March 2016 to January 2018 from Beijing Tongren Hospital affiliated to Capital Medical University have been selected. These lection includes 57 cases of HBV-related HCC, 61 cases of non- HBV-related HCC, 52 cases of HBV-related cirrhosis, 57 cases of chronic HBV, and 74 healthy persons in the same period. The levels of serum DCP, AFP and GP73 in each group were measured. Combined diagnosis of three indexes is better than single diagnosis, P<0.001. Using SVM mathematical diagnosis model, the specificity and sensitivity of diagnosing HBV-related HCC and healthy controls reached 98.7% and 97.6%, while the specificity and sensitivity of diagnosing HBV-related HCC and HBV-related cirrhosis reached 90.91% and 96.3%, respectively. Serum DCP, AFP and GP73 can be used independently as a useful reference for diagnosing HBV-related HCC patients. Combined detection of the three indicators can improve the sensitivity of HBV-related HCC diagnostic test. The SVM model can be used to diagnose and identify liver diseases at different stages.
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