Quantitative Analysis of Mast Cells in Benign Odontogenic Tumors


  • Kanupriya Gupta Faculty of Dental Sciences, IMS, BHU, Varanasi (U.P.), 221005, India
  • Jatin Gupta Faculty of Dental Sciences, IMS, BHU, Varanasi (U.P.), 221005, India
  • Rahul Agrawal Faculty of Dental Sciences, IMS, BHU, Varanasi (U.P.), 221005, India
  • Neha Verma Faculty of Dental Sciences, IMS, BHU, Varanasi (U.P.), 221005, India




Mast cells, odontogenic tumors, toluidine blue. .


The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using 1% toluidine blue for mast cells, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells are probably one of the major components of the Stromal scaffold in odontogenic tumors.


Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, Tang W, et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg 2007; 36: 20-5. https://doi.org/10.1016/j.ijom.2006.10.011 DOI: https://doi.org/10.1016/j.ijom.2006.10.011

Ledesma-Montes C, Mosqueda-Taylor A, Carlos-Bregni R, deLeon ER, Palma-Guzmán JM, Páez-Valencia C, Meneses-Garcia A. Ameloblastomas: a regional Latin-American multicentric study. Oral Dis 2000; 13: 303-7. https://doi.org/10.1111/j.1601-0825.2006.01284.x DOI: https://doi.org/10.1111/j.1601-0825.2006.01284.x

Caughey GH. Mast cell tryptases and chymases in inflammation and host defense. Immunol Rev 2007; 217: 141-54. https://doi.org/10.1111/j.1600-065X.2007.00509.x DOI: https://doi.org/10.1111/j.1600-065X.2007.00509.x

Norrby K. Mast cells and angiogenesis. APMIS 2002; 110: 355-71. https://doi.org/10.1034/j.1600-0463.2002.100501.x DOI: https://doi.org/10.1034/j.1600-0463.2002.100501.x

Conti P, Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tete S, Mastrangelo F, Perrella F, et al. Role of mast cells in tumor growth. Ann Clin Lab Sci 2007; 37: 315-22.

De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 429-47. https://doi.org/10.1002/path.1398 DOI: https://doi.org/10.1002/path.1398

Valent P, Schernthaner GH, Sperr WR, Fritsch G, Agis H,Willheim M, Buring HJ, et al. Variable expression of activation-linked surface antigens on human mast cells in health and disease. Immunol Rev 2001; 179: 74-81. https://doi.org/10.1034/j.1600-065X.2001.790108.x DOI: https://doi.org/10.1034/j.1600-065X.2001.790108.x

Mangia A, Malfettone A, Rossi R, Paradiso A, Raniere G, Simone G, Restal L. Tissue remodeling in breast cancer: human mast cell tryptase as an initiator of myofibroblasts differentiation. Histopathology 2011; 58: 1096-106. https://doi.org/10.1111/j.1365-2559.2011.03842.x DOI: https://doi.org/10.1111/j.1365-2559.2011.03842.x

Maltby S, Khazaie K, McNagny KM. Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta 2009; 1796: 19-26. https://doi.org/10.1016/j.bbcan.2009.02.001 DOI: https://doi.org/10.1016/j.bbcan.2009.02.001

Smith G, Smith AJ, Basu MK. Mast cells in human odontogenic cysts. J Oral Pathol Med 1989; 18: 274-8. https://doi.org/10.1111/j.1600-0714.1989.tb00396.x DOI: https://doi.org/10.1111/j.1600-0714.1989.tb00396.x

Li CY, Baek JY. Mastocytosis and fibrosis: role of cytokines. Int Arch Allergy Immunol. 2002; 127: 123-6. https://doi.org/10.1159/000048182 DOI: https://doi.org/10.1159/000048182

Ribatti D, Ennas MG, Vacca A, Ferreli F, Nico B, Orru S, Sirigu P. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest 2003; 33(5): 420-5. https://doi.org/10.1046/j.1365-2362.2003.01152.x DOI: https://doi.org/10.1046/j.1365-2362.2003.01152.x




How to Cite

Kanupriya Gupta, Jatin Gupta, Rahul Agrawal, & Neha Verma. (2019). Quantitative Analysis of Mast Cells in Benign Odontogenic Tumors. Journal of Analytical Oncology, 8, 35–38. https://doi.org/10.30683/1927-7229.2019.08.05