Chronic Inflammatory Mediators Induced Malignant Changes in Tumor Microenvironment of Oral Squamous Cell Carcinoma-New Insight
Keywords:Cytokines, Growth factors, NF-KB, STAT-3, TGF-β, PAMP, DAMP, Tumor associated macrophages, Tumor associated neutrophils, T lymphocytes, B lymphocytes, HIF-1α, AP-1, Tregs.
Oral cancer is a major cause of mortality and morbidity across the world. Because of extensive use of carcinogenic products such as Tobacco (Smoking or Chewable form), alcohol consumption and some cases due to infectious agents such as HPV (Human papilloma virus) induced oro-pharyngeal carcinoma. These carcinogens induce inflammatory changes in the inflammatory microenvironment of oral cavity. Oral Squamous cell carcinoma is the most common cancer of oral cavity. Chronic inflammatory mediators in tumor microenvironment are adaptive and innate immune cells such as macrophages, neutrophils, T- lymphocytes,mast cells,B-lymphocytes and their secreting factors such as proteases, ROS and cytokines, which in turn activates transcriptional factors (NF-KB,STAT-3) secreted by these immune cells and tumor cells bring about malignant changes. This article briefs about chronic inflammatory mediators in tumor microenvironment of oral Squamous cell carcinoma and their role in tumor progression.
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