Primary Squamous Cell Carcinoma of the Breast is a Rare and Special Entity

A Case Report from Arab Region with Aggressive Behavior and follow up 25 Months

Authors

  • Mervat Mahrous Departments of Oncology, King Fahad Hospital, Medina Munawara, Saudi Arabia
  • Tasabeeh Mohamed Departments of Oncology, King Fahad Hospital, Medina Munawara, Saudi Arabia
  • Ghassan Al SISI Department of surgery, King Fahad Hospital, Medina Munawara, Saudi Arabia
  • Ahmed Al-Hujaily Department of Pathology, King Fahad Hospital, Medina Munawara, Saudi Arabia
  • Samira AlSumani Department of Radiology, King Fahad Hospital, Medina Munawara, Saudi Arabia

DOI:

https://doi.org/10.6000/1927-7229.2018.07.03.1

Keywords:

Squamous cell carcinoma of the breast (SCCB), chemotherapy, rare malignancy

Abstract

Background: Primary squamous cell carcinoma of the breast (PSCCB) is a very rare malignancy of the breast. Pure squamous cell carcinoma of the breast can originate from skin adnexa, the nipple or the epithelium of deep-seated epidermoid cyst or squamous metaplasia on chronic inflammation background. Case Report: Our case is a 49-year-old female patient who presented with a highly suspicious lump in her left breast. Bilateral mammography and core biopsy were carried out. The core biopsy was revealed atypical cells and review inconclusive. Incisional biopsy was done and revealed squamous cell carcinoma of the breast (SCCB). Her metastatic work up at presentation was unremarkable. Left-side modified radical mastectomy was carried out. TNM staging was Stage IIa pT2N0M0 GIII, Estrogen receptors (ER) and Progesterone receptors were negative and HER2/Neu was negative as well (Triple negative). Pt had adjuvant chemotherapy and radiotherapy. Eight months later, she developed multiple brain metastasis as solitary site of metastasis, then after four months she developed hepatic and pulmonary deposits. Pt survived only 25 months since disease diagnosis. We report this case with relatively younger age to confirm that primary squamous cell carcinoma of the breast has special aggressive entity and this conjugant with few series. The treatment of primary SqCC of the breast does not differ from other common histological types of breast cancer so far. Conclusions: The prognosis of this disease is highly uncertain and the treatment options are unclear and controversial. There is inadequate literature and treatment guidelines. To our knowledge it is the first case to be reported from arab region with aggressive behavior and short survival period.

References

Louwman MW, Vriezen M, van Beek MW. Uncommon breast tumors in perspective: Incidence, treatment and survival in the Netherlands. Int J Cancer 2007; 121: 127-135. https://doi.org/10.1002/ijc.22625

Tavassoli FA, Devilee P, editors. Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003. World Health Organization Classification of Tumours. Pathology and Genetics; p. 1-433

Vu-Nishino H, Tavassoli FA, Ahrens WA, Haffty BG. Clinicopathologic features and long-term outcome of patients with medullary breast carcinoma managed with breast-conserving therapy (BCT). Int J Radiat Oncol Biol Phys 2005; 62(4): 1040-1047. https://doi.org/10.1016/j.ijrobp.2005.01.008

Kim MJ, Ro JY, Ahn SH, Kim HH, Kim SB, Gong G. Clinicopathologic significance of the basal-like subtype of breast cancer: a comparison with hormone receptor and Her2/neu-overexpressing phenotypes. Hum Pathol 2006; 37(9): 1217-1226. https://doi.org/10.1016/j.humpath.2006.04.015

Behranwala KA, Nasiri N, Abdullah N: Squamous cell carcinoma of the breast: Clinico-pathologic implications and outcome. Eur J Surg Oncol 2003; 29: 386-389. https://doi.org/10.1053/ejso.2002.1422

Yerushalmi R, Hayes MM, Gelmon KA. Breast carcinoma—rare types: review of the literature Ann Oncol 2009; 20(11): 1763-1770. First published online July 14, 2009. https://doi.org/10.1093/annonc/mdp245

Tayeb K, Saadi I, Kharmash M, El Omari-Alaoui H, El Ghazi E, Mansouri A,: Primary squamous cell carcinoma of the breast: Report of three cases. Cancer Radiother 2002; 6: 366-368. https://doi.org/10.1016/S1278-3218(02)00258-5

Cardoso F, Leal C, Meira A, Azevedo R, Mauricio MJ, Leal da Silva JM, Lopes C, Pinto Ferreira E. Squamous cell carcinoma of the breast. Breast 2000; 9: 315-319. https://doi.org/10.1054/brst.1999.0145

Gupta G, Malani AK, Weigand RT, Rangenini G. Pure primary squamous cell carcinoma of the breast: A rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast. Pathol Res Pract 2006; 6: 465-69. https://doi.org/10.1016/j.prp.2006.01.006

Moisidis E, Ahmed S, Carmalt H, et al. Primary squamous cell carcinoma of the breast. ANZ J Surg 2002; 72: 65-67. https://doi.org/10.1046/j.1445-2197.2002.02298.x

Murialdo R, Boy D, Musizzano Y, Tixi L, Murelli F, Ballestrero A. Squamous cell carcinoma of the breast: a case report. Cases Journal 2009; 2: 7336-7339.

Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V, Morat L, et al. Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res 2007; 27(1B): 547-555.

Menes T, Schachter J, Morgenstern S: Primary squamous cell carcinoma (SqCC) of the breast. Am J Clin Oncol 2003; 26: 571-573. https://doi.org/10.1097/01.coc.0000045809.85995.3B

Hennessy BT, Krishnamurthy S, Giordano S, Buchholz TA, Kau SW, Duan Z, Valero V, Hortobagyi GN. Squamous cell carcinoma of the breast. J Clin Oncol 2005; 23: 7827-7835. https://doi.org/10.1200/JCO.2004.00.9589

Geyer FC, Weigelt B, Natrajan R, Lambros MB, de Biase D, Vatcheva R, Savage K, et al. Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas. J Pathol 2010; 220(5): 562-573. https://doi.org/10.1002/path.2675

Banerjee S, Reis-Filho JS, Ashley S, Steele D, Ashworth A, Lakhani SR, Smith IE. Basal-like breast carcinomas: clinical outcome and response to chemotherapy. J Clin Pathol 2006; 59(7): 729-735. https://doi.org/10.1136/jcp.2005.033043

Yamaguchi R, Horii R, Maeda I, Suga S, Makita M, Iwase T, Oguchi M, et al. Clinicopathologic study of 53 metaplastic breast carcinomas: their elements and prognostic implications. Hum Pathol 2010; 41(5): 679-685. https://doi.org/10.1016/j.humpath.2009.10.009

Tsung S. Primary Pure Squamous Cell Carcinoma of the Breast Might Be Sensitive to Cisplatin-Based Chemotherapy. Case Rep Oncol 2012; 5(3): 561-565. https://doi.org/10.1159/000343745

Downloads

Published

2018-08-10

How to Cite

Mervat Mahrous, Tasabeeh Mohamed, Ghassan Al SISI, Ahmed Al-Hujaily, & Samira AlSumani. (2018). Primary Squamous Cell Carcinoma of the Breast is a Rare and Special Entity: A Case Report from Arab Region with Aggressive Behavior and follow up 25 Months . Journal of Analytical Oncology, 7(3), 37–42. https://doi.org/10.6000/1927-7229.2018.07.03.1

Issue

Section

Articles