Myeloid Derived Suppressor Cells in Oral Cancer: An Emerging Concept
Keywords:iNOS, Arginase 1, COX-2, HIF-1 Alfa, T regs, Peroxynitrate, S 100 A8/A9, ROS.
Myeloid derived suppressor cells (MDSC) are specialized immunoregulatorycells and major cause of immunosuppression in oral cancer tumor microenvironment. Which are generated by various mediators of chronic inflammation. MDSC exerts its effects by two mechanisms, first is enzymatic mechanism by two enzymes which are elevated in MDSC are arginaseand iNOS2, second is non-enzymatic mechanism by ROS, peroxynitrate ,L-selectin and interaction with other immune cells. It also has a role in progression of oral cancer by secreting inflammatory mediators. This article brief about the MDSC in immune regulation and tumor progression in oral cancer tumor microenvironment.
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