Evaluation of Concordance between Gleason Scores of Tansrectal Ultrasound Guided Biopsy and Radical Prostatectomy Samples in Prostate Cancer
DOI:
https://doi.org/10.6000/1927-7229.2018.07.01.2Keywords:
Gleason score, prostate biopsy, prostate cancer, PSA, radical prostatectomy.Abstract
Objective: In this study, we investigated the concordance between Gleason scores of transrectal ultrasound guided biopsy and radical prostatectomy specimens in patients diagnosed with prostate cancer via transrectal ultrasound guided biopsy and treated with radical prostatectomy in our clinic.
Material and Method: 115 patients were included in our study treated with radical prostatectomy for organ-confined prostate cancer between the dates of November 2011 and December 2014. Data of these patients are reviewed retrospectively.
Results: The average age of the patients was 61.8 ± 6.8 (43-76) years. The average body mass index of these patients were (BMI) 26.7 ± 3.34 (19.3 - 35.3) kg/m². Average PSA value was 6.6 ± 10.1 (1.4 - 80) ng/ml. Gleason scores of transrectal ultrasound guided biopsy and radical prostatectomy were observed concordant in 74 (64.3%) of 115 patients, while 41 (35.6%) were not concordant. Gleason score was decreased by 1 grade for 8.6% (10 patients) of patients, it was increased by 1 for 26.0% (30 patients) of patients and for 0.8% (1 patient) it was increased by 3.
Discussion: These findings indicate indicate that Gleason scores of transrectal ultrasound guided biopsy and prostatectomy specimens may be discordant.
References
Walsh PC, Retik BA, Vaughan ED, Wein AJ. Campbell’s uro-logy. 13th ed. Philadelphia: Saunders Co., 2012; 2704-2734.
Cooperberg MR, Presti Jr. JC, Shinohara K, Carroll PR. Neoplasm of the prostate gland. In: Tanagho EA, McAninch JW, (Eds.). Smith & Tanagho’s general urology. 18th ed. San Francisco: The McGraw-Hill Medical 2013; 350-379.
Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, et al. Cancer statistics, 2004. CA Cancer J Clin 2004; 54(1): 8-29. https://doi.org/10.3322/canjclin.54.1.8
Pound CR, Partin AW, Epstein JI, Walsh PC. Prostate-specific antigen after anatomic radical retropubic prostatectomy. Patterns of recurrence and cancer control. Urol Clin North Am 1997; 24(2): 395-406. https://doi.org/10.1016/S0094-0143(05)70386-4
Zeegers MP, Jellema A, Ostrer H. Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer 2003; 97(8): 1894-903. https://doi.org/10.1002/cncr.11262
Gleason DF, Mellinger GT. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 1974; 11(1): 58-64. https://doi.org/10.1016/S0022-5347(17)59889-4
Epstein JI, Carmichael M, Partin AW, Walsh PC. Is tumor volume an independent predictor of progression following radical prostatectomy? A multivariate analysis of 185 clinical stage B adenocarcinomas of the prostate with 5 years of followup. J Urol 1993; 149(6): 1478-81. https://doi.org/10.1016/S0022-5347(17)36421-2
Fernandes ET, Sundaram CP, Long R, Soltani M, Ercole CJ. Biopsy Gleason score: how does it correlate with the final pathological diagnosis in prostate cancer. Br J Urol 1997; 79(4): 615-7. https://doi.org/10.1046/j.1464-410X.1997.00126.x
Noguchi M, Stamey TA, McNeal JE, Yemoto CM. Relationship between systematic biopsies and histological features of 222 radical prostatectomy specimens: Lack of prediction of tumor significance for men with nonpalpable prostate cancer. J Urol 2001; 166(1): 104-10. https://doi.org/10.1016/S0022-5347(05)66086-7
Grossfeld GD, Chang JJ, Broering JM, Li YP, Lubeck DP, Flanders SC, et al. Under staging and under grading in a contemporary series of patients undergoing radical prostatectomy: Results from the cancer of the prostate strategic urologic research endeavor database. J Urol 2001; 165(3): 851-6. https://doi.org/10.1016/S0022-5347(05)66543-3
Gregori A, Vieweg J, Dahm P, Paulson DF. Comparison of ultrasound-guided biopsies and prostatectomy specimens: Predictive accuracy of Gleason score and tumor site. Urol Int 2001; 66(2): 66-71. https://doi.org/10.1159/000056573
San Francisco IF, DeWolf WC, Rosen S, Upton M, Olumi AF. Extended prostate needle biopsy improves concordance of Gleason grading between prostate needle biopsy and radical prostatectomy. J Urol 2003; 169(1): 136-40. https://doi.org/10.1016/S0022-5347(05)64053-0
Garnett JE, Oyasu R, Grayhack JT. The accuracy of diagnostic biopsy specimens in predicting tumor grades by Gleason’s classification of radical prostatectomy specimens. J Urol 1984; 131(4): 690-3. https://doi.org/10.1016/S0022-5347(17)50583-2
Spires SE, Cibull ML, Wood DP Jr, Miller S, Spires SM, Banks ER. Gleason histologic grading in prostatic carcinoma. Correlation of 18-gauge core biopsy with prostatectomy. Arch Pathol Lab Med 1994; 118(7): 705-8.
Bostwick DG. Gleason grading of prostatic needle biopsies. Correlation with grade in 316 matched prostatectomies. Am J Surg Pathol 1994; 18(8): 796-803. https://doi.org/10.1097/00000478-199408000-00006
Thicman D, Speers WC, Philpott PJ, S. Effect of the number of core biopsies of the prostate on predicting Gleason score of prostate cancer. hapiro HJ Urol 1996; 156(1): 110-3.
Cookson MS, Fleshner NE, Soloway SM, Fair WR. Correlation between Gleason score of needle biopsy and radical prostatectomy specimen: Accuracy and clinical implications. J Urol 1997; 157(2): 559-62. https://doi.org/10.1016/S0022-5347(01)65201-7
Pourmand G, Gooran S, Hossieni SR, Guitynavard F, Safavi M, Sharifi A, Mokhtari E. Correlation of Preoperative and Radical Prostatectomy Gleason Score: Examining the Predictors of Upgrade and Downgrade Results. Acta Medica Iranica 2017; 55(4).
Khoddami M, Khademi Y, Aghdam MK, Soltanghoraee H. Correlation between Gleason Scores in Needle Biopsy and Corresponding Radical Prostatectomy Specimens: A Twelve-Year Review. Iran J Pathol 2016; 11(2): 120-126.
