Intracellular Zinc Excess as One of the Main Factors in the Etiology of Prostate Cancer


  • Vladimir Zaichick Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyev Str. 4, Obninsk 249036, Kaluga Region, Russia
  • Sofia Zaichick Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyev Str. 4, Obninsk 249036, Kaluga Region, Russia: Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA
  • Sinclair Wynchank Strategic Health Innovation Partnerships, Medical Research Council, Tygerberg, 7505, Western Cape, South Africa



Human prostate gland, peripheral zone, prostatic cells, prostatic fluid, zinc, histologicalparameters, age-related changes in human prostate, prostate cancer.


 Numerous studies show that prevalence of prostate cancer (PCa) drastically increases with age, these malignant tumours are mainly formed in the peripheral zone of the prostate gland, and a high intake of red meat is associated with a statistically significant elevation in risk of PCa. The factors which cause all these well-specified features of the PCa are currently unclear. Here we describe one factor which can play an important role in etiology of malignant transformation of the prostate and is connected with the above-mentioned features of PCa. It is hypothesized that the prostatic intracellular Zn concentrations are probably one of the most important factors in the etiology of PCa. For an endorsement of our standpoint the estimation of changes of intracellular Zn concentrations over males lifespan was obtained using morphometric and Zn content data for the peripheral zone of prostate tissue, as well as Zn concentration in prostatic fluid. It was shown that the Zn concentrations in prostatic cells for men aged over 45 years are 10-fold higher than in those aged 18 to 30 years and this excessive accumulation of Zn may disturb the cells functions, resulting in cellular degeneration, death or malignant transformation.We hypothesize this excessive intracellular Zn concentration in cells of the prostate gland periphery has previously unrecognized and most important consequences, associated with PCa.


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How to Cite

Vladimir Zaichick, Sofia Zaichick, & Sinclair Wynchank. (2016). Intracellular Zinc Excess as One of the Main Factors in the Etiology of Prostate Cancer. Journal of Analytical Oncology, 5(3),  124–131.