Peritoneal Carcinomatosis and Multi-Organ Metastases are Prognostic Factors in Colorectal Cancer: A Retrospective Analysis

Authors

  • Omar Youssef The University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland
  • Virinder Kaur Sarhadi The University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland
  • Lauri Lehtimäki The University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland
  • Milja Tikkanen The University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland
  • Arto Kokkola The HUCH Gastrointestinal Clinic, Helsinki University Hospital, Helsinki, Finland
  • Pauli Puolakkainen The HUCH Gastrointestinal Clinic, Helsinki University Hospital, Helsinki, Finland
  • Gemma Armengol Unit of Biological Anthropology, Department of Animal Biology, Plant Biology and Ecology, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
  • Sakari Knuutila The University of Helsinki, Faculty of Medicine, Department of Pathology, Helsinki, Finland

DOI:

https://doi.org/10.6000/1927-7229.2016.05.01.1

Keywords:

Colorectal cancer, prognostic factors, peritoneal carcinomatosis, first line chemotherapy, multi-organ metastases.

Abstract

 Background: Peritoneal carcinomatosis and multi-organ metastases might be prognostic factors in patients with advanced colorectal cancer and inoperable metastases at diagnosis.

Methods: A retrospective study was performed to examine the relationship between patient clinical characteristics and prognosis in patients with colorectal cancer and indication for first-line systemic chemotherapy.

Results: One hundred and twelve patients were accrued. According to univariate analysis, peritoneal carcinomatosis, lack of primary tumour resection and multi-organ metastases were associated with poor overall survival. According to multivariate analysis, patients with peritoneal carcinomatosis and patients with multi-organ metastases had a shorter overall survival (12 vs 27.0 months, p<0.001 and 14,6 vs 27 months, p=0.007, respectively).

Conclusions: Our results indicate that presence of peritoneal carcinomatosis and multi-organ metastases are independent predictors of poor outcome for patients with colorectal cancer undergoing first line treatment with standard chemotherapy.

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Published

2016-01-03

How to Cite

Omar Youssef, Virinder Kaur Sarhadi, Lauri Lehtimäki, Milja Tikkanen, Arto Kokkola, Pauli Puolakkainen, Gemma Armengol, & Sakari Knuutila. (2016). Peritoneal Carcinomatosis and Multi-Organ Metastases are Prognostic Factors in Colorectal Cancer: A Retrospective Analysis. Journal of Analytical Oncology, 5(1),  5–13. https://doi.org/10.6000/1927-7229.2016.05.01.1

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