Decrease in Bilateral Corneal Deposits After Bortezomib/ Dexamethasone Chemotherapy in Monoclonal Gammopathy: Case Report

Authors

  • A. Klingenstein Ludwig-Maximilians University, Department of Ophthalmology, Klinikum der Universität München, Campus Innenstadt, Mathildenstr. 8, D-80336 Munich, Germany
  • W.J. Mayer Ludwig-Maximilians University, Department of Ophthalmology, Klinikum der Universität München, Campus Innenstadt, Mathildenstr. 8, D-80336 Munich, Germany
  • A. Kampik Ludwig-Maximilians University, Department of Ophthalmology, Klinikum der Universität München, Campus Innenstadt, Mathildenstr. 8, D-80336 Munich, Germany

DOI:

https://doi.org/10.6000/1927-7229.2012.01.01.15

Keywords:

Corneal deposits, crystallins, in vivo confocal microscopy, monoclonal gammopathy, paraproteinemia

Abstract

Purpose: To evaluate changes of bilateral crystalline corneal deposits via biomicroscopic photography and in vivo confocal microscopy (IVCM) after systemic chemotherapy in a patient with monoclonal gammopathy. Methods: Ophthalmological examination, slit-lamp biomicroscopic photography and IVCM of each corneal quadrant were performed before and after 4 cycles of combined bortezomib and dexamethasone chemotherapy. Results: IVCM revealed mainly subepithelial crystalline deposits not affecting keratocytes or antigen presenting cells. After therapy, corneal opacity in slit-lamp biomicroscopic photography and crystalline deposits decreased visibly. Visual acuity remained stable. Subjective symptoms (haziness, photophobia) improved. Conclusions: This patient suffered from initially unknown monoclonal gammopathy manifesting in bilateral corneal deposits. Crystalline corneal deposits may be associated with systemic disorders such as monoclonal gammopathy. Correct diagnosis is crucial as systemic treatment may improve not only ophthalmological symptoms. Penetrating keratoplasty alone may lead to relapse.

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Published

2012-01-28

How to Cite

A. Klingenstein, W.J. Mayer, & A. Kampik. (2012). Decrease in Bilateral Corneal Deposits After Bortezomib/ Dexamethasone Chemotherapy in Monoclonal Gammopathy: Case Report. Journal of Analytical Oncology, 1(1), 103–106. https://doi.org/10.6000/1927-7229.2012.01.01.15

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