Unveiling the Unpredicted and Uncontrolled Metastasis of Cancer Cells: A Minireview

• Pravin K. Naoghare

  Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, India

• Ajam Shekh

  Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, India

• Amit Bafana

  Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, India

• Kannan Krishnamurthi

  Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, India

• Saravanadevi Sivanesan

  Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur, India

 Cancer as an historical disease is known to occur since several hundred years and still prevails till date as one of the most feared diseases. Its occurrence and/or progression are considered as the outcome of the series of accumulated ocogenic changes in the cell those transform it from benign to invasive or metastatic. It has been observed that most of the metastatic cancers are not curable and the available drugs focus on steadying the tumour growth to prevent further metastasis. Metastasis remains the cause of around 90% of the cancer deaths. Fundamental understanding of metastasis and recent advancements in metastasis driven cancer research may help to strengthen and bring in practice the new and advanced approaches for cancer treatment. In view of this, we review in detail the molecular mechanism of metastasis, problems in diagnosing and treating metastasis, and recent developments in cancer biology. Future efforts in order to unveil the unpredicted and uncontrolled metastasis of cancer cells have also been summarised.

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