Template-Based Inverse PlanningSimulated Annealing for CT-Based High-Dose-Rate Brachytherapy of Cervical Cancer: Feasibility Study

• Kaiguo Yan

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Laura Doyle

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Haisong Liu

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Pramila Rani Anne

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Amy Harrison

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Yan Yu

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

• Junsheng Cao

  Department of Radiation Oncology, Kimmel Cancer Center (NCI-Designated), Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA, USA

 Purpose:To investigate the feasibility of using an inverse planning technique for CT-based ring and tandem high-dose rate brachytherapy of cervical cancer.

Methods and Materials:Two patients previously treated with high-dose-rate brachytherapy for cervical cancer were retrospectively identified for this study. Each patient had five intracavitary insertions using CT/MR-compatible tandem and ring applicators. The 6Gy isodose lines from the original clinical plans were converted into a structure set (S6) using MIMvista. Inverse plans were then generated in Oncentra using the inverse planning simulated annealing (IPSA) with S6 as the optimization target. The dose to 0.1cm³, 1cm³, 5cm³ of bladder (D_B0.1, D_B1, and D_B5) and rectum (D_R0.1, D_R1, D_R5) were determined from the dose volume histogram (DVH). Percentage of physician drawn clinical target volume (CTV) and S6 coverage (V_100CTV, V_100S6) were also recorded.

Results:The mean V_100%CTV of the original clinical plans and the inverse plans were 88.14% and 87.57%. The mean V_100%S6 of the original clinical plans and the inverse plans was 98.68% and 97.00%. The mean dose reduction for D_B0.1, D_B1 and D_B5 were 5.4%, 5.4%, and 4.7%, respectively. The mean dose reduction for D_R0.1, D_R1 and D_R5 were 6.4%, 5.5%, and 4.8%.

Conclusions:This work demonstrated the feasibility of this structure-based inverse planning. It can achieve comparable CTV coverage while reducing dose to critical structures. Once template structure set is constructed, this procedure can not only reduce planning time, but improve quality assurance by standardizing the procedure. This approach can be directly extended to other applicator-based brachytherapy procedures.

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