Anti-Cancer and Anti-Microbial Activity Studies of Some Complexes of Trimethoprim

• Ali El-Shekeil

  Department of Chemistry, Faculty of Science, Sana’a University, P.O. Box 12463, Sana’a, Yemen

• Abeer Omer

  Department of Chemistry, Faculty of Science, Sana’a University, P.O. Box 12463, Sana’a, Yemen

• Sama Al-Aghbari

  Department of Chemistry, Faculty of Science, Sana’a University, P.O. Box 12463, Sana’a, Yemen

• Omar Al-Shuja'a

  Department of Chemistry, Faculty of Applied Science, Thamar University, Thamar, Yemen

 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, trimethoprim (TMP), was reacted with Cu, Zn, Fe and Ti. The products were characterized by elemental (CHN) analysis, FTIR, magnetic moment measurements, conductance measurements, electronic spectra, ¹³C spectra. All complexes were investigated for their anti-bacterial activities against Gram-positive and Gram-negative bacteria and were also screened for their in vitro anti-cancer potential using Hela and PC3 cells. All the complexes showed excellent anti-bacterial activity even more than TMP while TMP-Ti displayed good cytotoxic activity in vitro against Hela cells and TMP-Cu showed moderate cytotoxicity against PC3 cells.

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